Table 2.
Additional resources available for potential collaboration with the Hypertension Strategically Focused Research Network centers.
| Center and Project | Resource |
|---|---|
| Cincinnati Children’s Hospital | |
| Population science project | Princeton study, National Growth and Health Study (longitudinal studies of cardiovascular risk factors since youth) |
| Clinical science project | International Pediatric Hypertension Association headquarters brings together experts in Pediatric hypertension and ambulatory blood pressure monitoring |
| Basic science project | Center for Pediatric Genomics including DNA sequencing & genotyping core, Pyrosequencing lab, Gene expression core, metabolomics core |
| Medical College of Wisconsin | Technologies for DNA methylation sequencing, RNA-seq and data analysis |
| Population science project | DNA in original African American cohort (n=3,000), extensive phenotyping in 550 of the cohort |
| Clinical science project | In vivo and in vitro vascular function studies in human subjects |
| Basic science project | Experiments to assess arterial blood pressure and renal disease phenotypes in conscious rats and mice. |
| University of Alabama at Birmingham | |
| Population science project | Jackson Heart Study Vanguard center, Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, Coronary Artery Risk Development in Young Adults (CARDIA), ABPM and HBPM data though Hypertension SFRN partnership with Columbia University investigators |
| Clinical science project | Antihypertensive Lipid-Lowering to Prevent Heart Attack Trial (ALLHAT) network lead Systolic Blood Pressure Intervention Trial (SPRINT) network lead Studies of resistant and refractory hypertension |
| Basic science project | Studies of renal function and measurements of nitric oxide and reactive oxygen species in animal models of hypertension |
| University of Iowa | |
| Population science project | University of Iowa Maternal Fetal Tissue Bank: Prospectively collected maternal, paternal, and fetal biosamples throughout gestation including blood, urine, amniotic fluid, placenta, and cord blood that are deeply clinically annotated from UI patients as previously described (Santillan 2014, see footnote); biomarker identification, testing, and analysis; immunologic and primary placental mechanistic studies; preclinical therapeutic studies in preeclampsia. |
| Clinical science project | Cross-sectional and various short-term intervention studies with vascular, autonomic, metabolic, dietary, physical activity and cellular/tissue (serum/plasama endothelial, adipose, blood mononuclear) outcomes in humans with obesity, prehypertension/hypertension, prediabetes, aging, pregnancy or chronic anxiety. |
| Basic science project | UI Center for Hypertension Research which includes studies of autonomic and vascular function in animal models of hypertension and development of novel pharmacological and genetic models of hypertensive disorders |
Santillan MK, Leslie KK, Hamilton WS, Boese BJ, Ahuja M, Hunter SK, Santillan DA. “Collection of a lifetime: A practical approach to developing a longitudinal collection of women’s healthcare biological samples”. European journal of obstetrics, gynecology, and reproductive biology. 2014;179:94–99