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. 2016 Nov 28;9:1121–1129. doi: 10.2147/JPR.S118412

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© 2016 Shi et al. This work is published and licensed by Dove Medical Press Limited

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The development of mechanical hyperalgesia and allodynia in rats (n = 10/rat type).

Notes: All behavioral tests were conducted on Thursday and Friday of each week from week 7 to week 13 for 7 consecutive weeks. (A) Mechanical hyperalgesia was quantified using an Ugo Basile analgesiometer. (B) Mechanical allodynia was assessed using an Ugo Basile Dynamic Plantar Esthesiometer. *The significant difference relative to lean rats (ANOVA single week main effect, p < 0.05).

Abbreviations: ANOVA, analyses of variance; ZDF, Zucker diabetic fatty.