Table 1.
Monitoring body weight and blood glucose levels of ZDF rats
| Age (weeks) | Body weight (g)
|
Fasting blood glucose (mmol/L)
|
||||
|---|---|---|---|---|---|---|
| Lean rats | ZDF rats | ZDF rats (ceftriaxone) | Lean rats | ZDF rats | ZDF rats (ceftriaxone) | |
| 7 | 251.5 ± 9.1 | 268.4 ± 8.3 | 269.1 ± 7.6 | 4.82 ± 0.98 | 5.12 ± 1.23 | 5.21 ± 1.43 |
| 8 | 258.8 ± 8.7 | 322.9 ± 7.6* | 323.5 ± 7.9* | 4.76 ± 0.87 | 6.55 ± 1.56 | 6.51 ± 1.62 |
| 9 | 281.6 ± 10.1 | 374.6 ± 8.7* | 375.4 ± 8.1* | 4.73 ± 1.01 | 9.89 ± 1.87* | 9.66 ± 1.78* |
| 10 | 308.4 ± 9.8 | 378.2 ± 7.4* | 380.1 ± 8.1* | 4.62 ± 0.98 | 13.87 ± 2.10* | 13.79 ± 1.98* |
| 11 | 338.7 ± 7.5 | 380.4 ± 8.6* | 382.6 ± 7.7* | 4.81 ± 1.05 | 16.99 ± 2.60* | 17.02 ± 2.51* |
| 12 | 359.3 ± 8.9 | 385.5 ± 8.4* | 387.1 ± 7.4* | 4.68 ± 0.79 | 17.74 ± 2.54* | 18.03 ± 2.47* |
| 13 | 370.5 ± 8.5 | 379.1 ± 9.2 | 382.1 ± 8.3 | 4.78 ± 0.85 | 18.06 ± 2.72* | 18.24 ± 2.29* |
Notes: Upon arrival, ZDF and lean rats were monitored for body weight daily and blood glucose every week. Rats were fasted for 3 h prior to the collection of blood from the tail. The onset of diabetic conditions was defined as blood glucose levels >13.3 mmol/L.
*
The significant difference relative to lean rats (ANOVA main and interaction effects, p < 0.05).
Abbreviations: ANOVA, analyses of variance; ZDF, Zucker diabetic fatty.