Figure 6. Ganetespib shows differential effects with CRT in H460 and A549 xenografts.

Ncr nude mice were injected with 1 × 10⁶ H460 cells or 5 × 10⁶ A549 subcutaneously in the right leg. When tumor volume reached around 100 mm³ for H460 or 150 mm³ for A549, mice bearing established xenograft (n=4–10/group) were exposed to radiation at 2 Gy daily for 5 days, with or without i.p. 30 mg/kg Carboplatin + 10 mg/kg Paclitaxel 1×/week for 2 weeks and combined with i.v. 100 mg/kg ganetespib 1×/week for 2 weeks, either alone or in combination. Tumor volumes are indicated as average of each treatment group and the error bars are the SEM.