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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Trends Mol Med. 2016 Nov 4;22(12):1077–1090. doi: 10.1016/j.molmed.2016.10.005

Table 1.

Nosocomial Pathogens and their Siderophores.

Nosocomial
Pathogens		 Types of
Disease		 Antibiotic
Resistance		 Siderophores Siderophore
Receptor
(OMR)
Gram-negative Pseudomonas
aeruginosa

  • pneumonia

  • septicemia

  • urinary tract infection

 Carbapenem Pyoverdine FpvA
Pyochelin FptA
Klebsiella
pneumoniae

  • wound infections

  • pneumonia

  • septicemia

  • urinary tract infections

 Carbapenem Aerobactin IutA
Yersiniabactin FyuA
Enterobactin FepA
Salmochelin IroN
Acinetobacter
baumannii

  • pneumonia

  • wound infections

  • bone infections

 Carbapenem Acinetobactin BauA
Fimsbactin n.d.
Baumannoferrins n.d.
Escherichia
coli

  • urinary tract infections

  • wound infections

  • septicemia

 Fluoroquinolone
Carbapenem
Cephalosporin		 Enterobactin FepA
Salmochelin IroN
Aerobactin IutA
Yersiniabactin FyuA
Gram-positive Staphylococcus
aureus

  • septicemia

  • gastrointestinal infections

  • urinary tract infections

  • wound infections

  • pneumonia

  • osteomyelitis

  • endocarditis

 Methicillin
Vancomycin		 Staphyloferrin A HtsA
Staphyloferrin B SirA
Staphylopine CntA
Mycobacteria Mycobacterium
tuberculosis

  • tuberculosis

 Isoniazid
Rifampicin
Ethambutol
Pyrazinamide
Streptomycin
Ofloxacin
Kanamycin		 Mycobactin n.d.
Carboxy-
mycobactin		 n.d.

n.d: not determined