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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Cancer Res. 2016 Oct 6;76(23):6911–6923. doi: 10.1158/0008-5472.CAN-16-0810

Figure 3. Rictor-deficient PanINs display increased nuclear expression of CDK inhibitors and decreased nuclear expression of BMI1.

Figure 3

(A-D) Quantification of nuclear staining in PanIN1 lesions in 4- (left) and 8- (right) month old KC and KC RictorΔ/Δ mice. (A) p16Ink4a, (B) p21Cip, (C) p27Kip1 and (D) BMI1. **p<0.01, ***p<0.001 as determined by student’s t-test in individual comparisons of cohorts. (E) Doubling time of a PanIN-derived cell line 4-6 days following shRNA-mediated Rictor knockdown. P values determined by counter variance analysis of inverse slopes. (F) Senescence-associated β-galactosidase positivity in a PanIN-derived cell line 4 days following shRNA-mediated Rictor knockdown. **p<0.01, ***p<0.001 as determined by student’s t-test.