Fig. 5.

Red blood cell cyanide, plasma thiocyanate, and plasma cobinamide concentrations in oral cyanide-exposed rabbits. Rabbits received oral cyanide with or without sodium bicarbonate and dinitrocobinamide or aquohydroxocobinamide at time zero, and then plasma cobinamide (a), plasma thiocyanate (b), and red blood cell cyanide (c and d) concentrations were measured at the indicated times. In a and the inset of c, data are shown for group 1 animals (cyanide alone with saline), group 2 animals (cyanide plus single bicarbonate administration), and group 3 animals (cyanide with double bicarbonate administration); the x-axis ends at 30 min because these animals had all died by that time. The other panels show data for group 4 (cyanide plus single bicarbonate administration and dinitrocobinamide) and group 5 animals (cyanide plus single bicarbonate administration and aquohydroxocobinamide) and show the full 90-min time scale on the x-axis