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Estimated marginal means of the mediastinal blood pool (MBP) and liver SUVmean in patients with high tumor burden (greater than 1 SD above the median MTV) and low tumor burden at baseline. Each group showed a significantly different pattern of change in the SUVmean of the MBP and liver along the course of chemotherapy (repeated measures ANOVA test, between-subject effects p = 0.001, 0.001 respectively)
