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. 2016 Dec 2;22:1375–1386.

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Copyright © 2016 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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Angiographic analysis of the effect of Islet-1 siRNA on retinal neovascularization in the mouse. A: Room air–raised mice with normal retinal vessel structure. B: In the murine model of oxygen-induced retinopathy (OIR), neovascular tufts (indicated by the arrow) appear as hyperfluorescence at the junction between the perfused and non-perfused areas (indicated with a star). C: The murine OIR model with injection of negative control siRNA. Neovascular tufts are apparent at the junction between the perfused and non-perfused areas. D: The murine OIR model injected with siRNA targeting insulin gene enhancer protein ISL-1 (Islet-1). E: The red area indicates the non-perfusion area. F: The non-perfusion areas were reduced after intravitreal injection of siRNA against Islet-1 compared with that of the murine model of OIR (★p<0.05).