Table 2.
The Response shift effect for the QLQ-C30 questionnaire after three and six months for all patients and three main categories of the anchor
| QLQ-C30 | After 3 months | After 6 months | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Between T0 and T1 | Between T1 and T2 | |||||||||
| N | RS (SD) | 95%CI | P-value | ES | N | RS (SD) | 95% CI | P-value | ES | |
| GHS | 251 | 3.82 (17.85) | 0.02 | 0.20 | 251 | −0.03 (21.04) | 0.97 | 0 | ||
| Little worse | 71 | 3.87 (15.86) | (1, 7) | 0.24 | 0.25 | 51 | −8.33 (19.22) | (−13, −4) | 0.03 | −0.42 |
| No change | 43 | 6.78 (15.67) | (3, 11) | 0.08 | 0.40 | 50 | 8 (19.04) | (3, 13) | 0.03 | 0.42 |
| Little better | 58 | 1.29 (17.51) | (−3, 5) | 0.67 | 0.08 | 67 | −0.25 (21.61) | (−5, 4) | 0.80 | −0.01 |
| Physical functioning | 255 | 1.54 (12.95) | 0.30 | 0.11 | 255 | −5.2 (12.86) | 0 | −0.32 | ||
| Little worse | 73 | −0.53 (11.11) | (−3, 2) | 0.49 | −0.05 | 53 | −9.56 (10.42) | (−12, −7) | 0 | −0.52 |
| No change | 46 | 1.30 (13.67) | (−2, 5) | 0.17 | 0.09 | 51 | −2.29 (8.5) | (−4, 0) | 0.13 | −0.26 |
| Little better | 57 | 3.83 (14.47) | (1, 7) | 0.45 | 0.28 | 69 | −3.94 (14.71) | (−7, −1) | 0.04 | −0.25 |
| Role functioning | 253 | 6.06 (21.71) | 0 | 0.32 | 253 | −8.17 (27.07) | 0 | −0.29 | ||
| Little worse | 73 | 6.62 (19.98) | (3, 11) | 0.04 | 0.46 | 51 | −15.69 (28.95) | (−22, −9) | 0 | −0.52 |
| No change | 46 | 3.26 (16.34) | (−1, 7) | 0.07 | 0.19 | 51 | −1.96 (18.45) | (−6, 2) | 0.67 | −0.11 |
| Little better | 55 | 10 (26.57) | (4, 16) | 0.05 | 0.45 | 68 | −5.88 (26.67) | (−11, 0) | 0.24 | −0.21 |
| Emotional functioning | 254 | −7.56 (21.03) | 0 | −0.29 | 254 | 2.20 (22.68) | 0.20 | 0.09 | ||
| Little worse | 72 | −9.34 (20.97) | (−13, −5) | 0 | −0.38 | 52 | −5.66 (19.77) | (−10, −1) | 0.16 | −0.24 |
| No change | 44 | −8.52 (17.14) | (−13, −4) | 0.03 | −0.42 | 50 | 8.94 (21.58) | (4, 14) | 0.04 | 0.47 |
| Little better | 59 | −11.11 (23.15) | (−16, −6) | 0.01 | −0.43 | 69 | 5.68 (21.83) | (1, 10) | 0.10 | 0.23 |
| Cognitive functioning | 254 | −3.94 (16.85) | 0.01 | −0.19 | 254 | −3.08 (20.03) | 0.04 | −0.15 | ||
| Little worse | 73 | −5.48 (20.04) | (−9, −2) | 0.08 | −0.26 | 52 | −10.58 (21.9) | (−16, −5) | 0.02 | −0.42 |
| No change | 44 | −1.52 (10.67) | (−4, 1) | 0.69 | −0.11 | 50 | −2.33 (16.5) | (−6, 2) | 0.35 | −0.16 |
| Little better | 57 | −5.85 (19.29) | (−10, −2) | 0.08 | −0.27 | 69 | 0.97 (18.28) | (−3, 5) | 0.98 | 0.05 |
| Social functioning | 249 | 5.09 (19.43) | 0 | 0.28 | 249 | −5.96 (24.47) | 0.01 | −0.23 | ||
| Little worse | 72 | 5.32 (19.94) | (1, 9) | 0.05 | 0.39 | 52 | −10.90 (25.54) | (−17, −5) | 0.02 | −0.40 |
| No change | 42 | 3.17 (14.37) | (−1, 7) | 0.08 | 0.24 | 49 | −4.76 (16.67) | (−9, −1) | 0.40 | −0.22 |
| Little better | 59 | 3.67 (20.55) | (−1, 8) | 0.59 | 0.18 | 68 | −1.23 (24.32) | (−6, 4) | 0.91 | −0.05 |
| Financial difficulties | 240 | −1.11 (15.32) | 0.30 | −0.08 | 240 | 2.50 (16.26) | 0.22 | 0.12 | ||
| Little worse | 69 | −1.45 (12.04) | (−4, 1) | 0.58 | −0.14 | 49 | 8.16 (24.09) | (2, 14) | 0.13 | 0.30 |
| No change | 41 | −1.63 (7.27) | (−4, 0) | 0.31 | −0.31 | 47 | −0.71 (4.86) | (−2, 0) | 0.57 | −0.15 |
| Little better | 58 | 0.57 (15.91) | (−3, 4) | 0.86 | 0.03 | 66 | −1.01 (16.51) | (−4, 2) | 0.82 | −0.05 |
| Fatigue | 254 | −1.20 (19.42) | 0.51 | −0.06 | 254 | 10.83 (23.93) | 0 | 0.41 | ||
| Little worse | 73 | −4.57 (21.36) | (−9, 0) | 0.31 | −0.33 | 53 | 19.92 (23.23) | (15, 25) | 0 | 0.85 |
| No change | 46 | −2.17 (15.29) | (−6, 2) | 0.62 | −0.12 | 51 | 3.70 (20.08) | (−1, 8) | 0.32 | 0.20 |
| Little better | 57 | −4.58 (21.29) | (−9, 0) | 0.35 | −0.23 | 68 | 9.97 (23.76) | (5, 15) | 0.01 | 0.44 |
| Nausea and vomiting | 255 | −1.37 (13.59) | 0.26 | −0.13 | 255 | 3.59 (17.65) | 0 | 0.19 | ||
| Little worse | 74 | −0.45 (15.35) | (−3, 3) | 0.71 | −0.05 | 53 | 4.09 (14.58) | (1, 7) | 0.09 | 0.26 |
| No change | 46 | 0.72 (9.91) | (−2, 3) | 1 | 0.04 | 51 | 0.98 (10.23) | (−1, 3) | 0.10 | 0.10 |
| Little better | 57 | −5.26 (15.16) | (−9, −2) | 0.05 | −0.87 | 70 | 6.67 (25.44) | (2, 12) | 0.05 | 29 |
| Pain | 260 | −3.33 (22.51) | 0.14 | −0.16 | 260 | 5.83 (22.2) | 0 | 0.23 | ||
| Little worse | 75 | −4.67 (21.32) | (−9, −1) | 0.29 | −0.24 | 54 | 15.43 (26.27) | (9, 21) | 0 | 0.56 |
| No change | 46 | 1.45 (18.2) | (−3, 6) | 0.83 | 0.09 | 52 | 2.24 (13.21) | (−1, 5) | 0.30 | 0.18 |
| Little better | 57 | −7.31 (23.57) | (−13, −2) | 0.16 | −0.35 | 70 | −0.24 (23.14) | (−5, 4) | 0.80 | −0.01 |
| Dyspnea | 251 | 1.20 (15.16) | 0.59 | 0.06 | 251 | 3.98 (22.4) | 0.03 | 0.17 | ||
| Little worse | 73 | 2.28 (15.04) | (−1, 5) | 0.38 | 0.11 | 52 | 3.85 (27.74) | (−3, 10) | 0.14 | 0.17 |
| No change | 45 | 0 (12.31) | (−3, 3) | 0.77 | 0 | 51 | 0.65 (10.52) | (−2, 3) | 0.79 | 0.05 |
| Little better | 55 | 0.61 (17.56) | (−3, 5) | 0.77 | 0.03 | 67 | 3.98 (22.11) | (−1, 8) | 0.51 | 0.17 |
| Insomnia | 249 | 6.83 (30.64) | 0.01 | 0.22 | 249 | 3.08 (30.41) | 0.30 | 0.10 | ||
| Little worse | 69 | 2.42 (29.33) | (−3, 8) | 0.49 | 0.08 | 52 | 10.9 (37.18) | (2, 2) | 0.07 | 0.33 |
| No change | 46 | 7.25 (26.21) | (1, 14) | 0.27 | 0.25 | 50 | 3.33 (25.42) | (−3, 9) | 0.24 | 0.18 |
| Little better | 55 | 7.88 (37.93) | (−1, 16) | 0.11 | 0.27 | 67 | −1.49 (29.83) | (−8, 5) | 0.74 | −0.05 |
| Appetite loss | 249 | 2.28 (21.05) | 0.23 | 0.11 | 249 | 4.69 (22.2) | 0.03 | 0.19 | ||
| Little worse | 73 | 0.91 (20.77) | (−3, 5) | 0.55 | 0.06 | 53 | 13.84 (24.84) | (8, 20) | 0 | 0.51 |
| No change | 46 | 4.35 (13.35) | (1, 8) | 0.19 | 0.22 | 50 | 0.67 (15.78) | (−3, 4) | 0.98 | 0.03 |
| Little better | 54 | 1.85 (22.82) | (−3, 7) | 0.79 | 0.09 | 68 | 1.96 (21.46) | (−2, 6) | 0.74 | 0.09 |
| Constipation | 247 | 0 (22.61) | 0.87 | 0 | 247 | 4.18 (25.89) | 0.05 | 0.16 | ||
| Little worse | 68 | −4.90 (18.45) | (−9, −1) | 0.19 | −0.26 | 48 | 4.17 (25.38) | (−2, 10) | 0.29 | 0.16 |
| No change | 42 | 2.38 (18.61) | (−2, 7) | 0.42 | 0.11 | 48 | 2.08 (14.43) | (−1, 6) | 0.43 | 0.15 |
| Little better | 58 | 0 (27.22) | (−6, 6) | 0.87 | 0 | 70 | 2.86 (35.32) | (−4, 10) | 0.71 | 0.10 |
| Diarrhea | 248 | 2.42 (14.99) | 0.09 | 0.15 | 248 | 0.94 (20.28) | 0.42 | 0.06 | ||
| Little worse | 71 | 3.29 (16.09) | (0, 6) | 0.28 | 0.18 | 48 | 3.47 (14.16) | (0, 7) | 0.22 | 0.23 |
| No change | 43 | 1.55 (12.50) | (−2, 5) | 0.54 | 0.13 | 48 | −0.69 (14.57) | (−4, 3) | 0.98 | −0.07 |
| Little better | 56 | 2.98 (17.15) | (−1, 7) | 0.34 | 0.16 | 69 | 0 (26.81) | (−5, 5) | 0.86 | 0 |
GHS global health status, RS response shift, SD standard deviation, CI confidence interval, ES effect size