. 2016 Dec 3;14:167. doi: 10.1186/s12955-016-0569-5

Table 7.

MID for QLQ-C30 and QLQ-BR23 questionnaires after 3 and 6 months compared to a threshold of 5 points

	After 3 months		After 6 months
	Observed changes	Adjusted changes	Observed changes	Adjusted changes
QLQ-C30
Global Health Status	16	12^a	0.5	8^a
Physical functioning	12	12^a	0.4	9^a
Role functioning	26	19^a	2	18^a
Cognitive functioning	5	11^a	1	10^a
Social functioning	20	15^a	1	10^a
Emotional functioning	3.5	6^a	0.5	6^a
Fatigue	27	23^a	0.2	20^a
Pain	14	9^a	2	17^a
Dyspnea	9	11^a	4	8^a
Insomnia	6	8^a	4	15^a
Financial difficulties	10	8^a	3	5^a
Appetite loss	10	11^a	10	4
Constipation	15	10^a	1	3
Nausea and vomiting	9	8^a	3	1
QLQ-BR23
Body image	20	15^a	0.4	11^a
Sexual functioning	7	7^a	0.4	11^a
Systemic therapy side effects	19	20^a	3	10^a
Breast symptoms	14	18^a	4	6^a
Arm symptoms	8	9^a	0.6	11^a
Sexual enjoyment	14	12^a	13	15^a
Future perspectives	7	9^a	3	0.7

^a indicates that the MID stayed or became greater than 5 points when the response shift effect was taken into account