Table 2. Subnetwork analysis for the KEGG arginine and proline metabolism pathway with systolic blood pressure.
| UK10K | TwinsUK | ALSPAC | ||||
|---|---|---|---|---|---|---|
| Genes in Subnetwork | Variantsa | P-value | Variantsa | P-value | Variantsa | P-value |
| CPS1, NOS1, NOS2, NOS3, ALDH9A1, ARG2, ALDH18A1, ALDH1B1, ALDH2, ALDH7A1, ALDH4A1, GOT1 and GOT2 | 57 | 1.58 × 10−4 | 38 | 4.00 × 10−3 | 40 | 0.03 |
| PRODH2, NOS1, NOS2, NOS3, PYCR1, ALDH9A1, ALDH4A1, ALDH2, ALDH7A1 and ALDH1B1 | 25 | 0.02 | 18 | 0.16 | 20 | 0.15 |
| GLUD1, CKM, CKMT2, CKB, ALDH1B1, ALDH7A1, ALDH2, ALDH9A1, ALDH4A1 and GOT2 | 34 | 1.30 × 10−3 | 25 | 0.02 | 26 | 0.06 |
a
Variants=number of variants analysed, UK10K=all individuals within UK10K project, TwinsUK=only TwinsUK partition of the UK10K project, ALSPAC=only ALSPAC partition of the UK10K project, P-value=P-values according to SKAT-O test.