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. Author manuscript; available in PMC: 2017 Feb 28.
Published in final edited form as: Nature. 2016 Aug 31;537(7621):544–547. doi: 10.1038/nature19353

Figure 3. Fumarate triggers EMT in FH-proficient cells.

Figure 3

miRNA methylation (a) and expression (b, e); EMT transcription factors (c, f) and EMT markers (d, g) levels from MMF-treated cells. Results were obtained from 3 independent cultures. qPCRs are presented as RQ with max values, normalised for Snord95 (mouse) or SNORD95 (human) for miRNAs, and for β-actin for mRNA. p-values were calculated using unpaired t-test. *P ≤0.05, **P ≤0.01, ***P ≤0.001, ****P≤0.0001. For gel source data, see Supplementary Figure 1. For Raw data see SI Table 2.