Extended Data Table 2.

Refinement statistics for the cryo-EM structures

	Active	Non-Active 1	Non-Active 2	Class X	Class Y
PDB ID	5FXG	5FXH	5FXI	5FXJ	5FXK
EMDB ID	EMD-3352	EMD-3353	EMD-3354	EMD-3355	EMD-3356
Refinement
Resolution (Å)	6.8	6.1	6.4	6.5	6.4
Map to Model CC	0.77	0.79	0.80	0.78	0.80
No. atoms
Protein	12,693	15,578	15,381	15,475	15,598
R.m.s deviations
Bond lengths (Å)	0.003	0.006	0.003	0.004	0.005
Bond angles (°)	0.55	0.55	0.60	0.58	0.55
Ramachandran
Favored (%)	88.3	90.4	90.2	88.0	88.8
Allowed (%)	11.5	9.2	9.4	11.4	10.7
Disallowed (%)	0.2	0.5	0.4	0.6	0.5