Table 1.

Body weight and fecal hemoglobin measurements from in vivo studies

SKOV3ip1 cells/nude mice	Body weight (g)	Fecal Hb (mg/g feces)
Control	23.25 ± 0.71	0.32
Aspirin-PC	22.74 ± 0.62	0.23
Bev	22.42 ± 0.87	0.24
Aspirin-PC/Bev	21.65 ± 0.45	0.28
ID8 cells/C57BL-6 mice
Control	23.65 ± 0.62	0.34
Aspirin	21.64 ± 0.32	0.34
Aspirin-PC	21.08 ± 0.52	0.34
B20	20.00 ± 0.13	0.26
Aspirin/B20	19.77 ± 0.16	0.26
Aspirin-PC/B20	19.63 ± 0.22	0.29
Hey A8 cells/nude mice
Control	26.44 ± 0.53	0.95
Aspirin	25.15 ± 0.65	1.75
Aspirin-PC	24.99 ± 0.64	0.91
Bev	26.84 ± 0.39	0.91
Aspirin/Bev	25.15 ± 0.62	0.89
Aspirin-PC/Bev	24.40 ± 0.67	0.93

NOTE: Body weight in grams at the termination of the study is expressed as the mean ± standard error of the mean for N=10 mice per group. Fecal hemoglobin (Hb) was measured from pooled samples collected from group cages, and is expressed as mg Hb per gram of feces for each group. For comparison, these Hb values are considered baseline and are much lower than values typically obtained from animals chronically treated with a higher dose NSAID that induces GI bleeding (ie, 2.5 to 15 mg Hb/g feces).