Table 1. Regulators of Axon Regeneration in C. elegans.

Regulators of C. elegans axon regeneration are listed, along with their role in axon regeneration. For simplicity, the table does not include all identified regulators.

	Gene	Description	Neuron	Role in Regeneration	Reference
Calcium and cAMP Signaling	egl-19	Voltage-gated calcium channel alpha1 subunit	PLM	Required	Ghosh-Roy et al., 2010
	acy-1	Adenylyl cyclase	PLM	Required	Ghosh-Roy et al., 2010
	cAMP	cyclic AMP	PLM	Required	Ghosh-Roy et al., 2010
	kin-2	PKA subunit	PLM	Inhibitor	Ghosh-Roy et al., 2010; Chen et al., 2011
	itr-1	Inositol triphosphate receptor	PLM	Required	Ghosh-Roy et al., 2010
	pde-4	cAMP phosphodiesterase	PLM	Inhibitor	Ghosh-Roy et al., 2010
	gsa-1	Heterotrimeric G protein alpha subunit Gs	PLM	Required	Ghosh-Roy et al., 2010
	jun-1	bZIP transcription factor	PLM	Required	Ghosh-Roy et al., 2010
	crt-1	Calreticulin	ALM	Required	Pinan-Lucarre et al., 2012
	unc-68	Ryanodine receptor	ALM	Required	Sun et al., 2014
MLK Signaling	vhp-1	MAPK phosphatase	GABA	Inhibitor	Nix et al., 2011
	svh-1	HGF, MSP, and plasminogen family	GABA	Required	Li et al., 2012
	svh-2	Receptor tyrosine kinase	GABA	Required	Li et al., 2012
	faah-1	Fatty acid amide hydrolase	GABA	Required	Pastuhov et al., 2012
	ets-4	ETS transcription factor	GABA	Required	Li et al., 2015
	mlk-1	MAPKKK	GABA	Required	Hammarlund et al., 2009; Nix et al., 2011
	mek-1	MAPKK	GABA	Required	Hammarlund et al., 2009; Nix et al., 2011
	kgb-1	MAPK	GABA	Required	Nix et al., 2011
	fos-1	bZIP transcription factor	GABA	Required	Nix et al., 2014
	goa-1	Heterotrimeric G protein alpha subunit Go Heterotrimeric G protein alpha subunit Go Heterotrimeric G protein alpha subunit Go Heterotrimeric G protein alpha subunit Go Heterotrimeric G protein alpha subunit Go	GABA	Inhibitor	Pastuhov et al., 2012
	egl-30	Heterotrimeric G protein alpha subunit Gq Heterotrimeric G protein alpha subunit Gq Heterotrimeric G protein alpha subunit Gq Heterotrimeric G protein alpha subunit Gq Heterotrimeric G protein alpha subunit Gq	GABA	Required	Pastuhov et al., 2012
	egl-8	Phospholipase C beta	GABA	Required	Pastuhov et al., 2012
	tpa-1	Protein kinase C	GABA	Required	Pastuhov et al., 2012
DLK Signaling	rpm-1	E3 ubiquitin ligase	GABA	Inhibitor	Hammarlund et al., 2009; Yan et al., 2009
	dlk-1	MAPKKK	GABA, PLM	Required	Hammarlund et al., 2009; Yan et al., 2009
	mkk-4	MAPKK	GABA, PLM	Required	Hammarlund et al., 2009; Yan et al., 2009
	pmk-3	MAPK	GABA, PLM	Required	Hammarlund et al., 2009; Yan et al., 2009
	mak-2	MAPKAP kinase	PLM	Required	Yan et al., 2009
	cebp-1	bZIP CCAAT/enhancer-binding protein	PLM	Required	Yan et al., 2009
Cytoskeletal Dynamics	mek-7	β-TUBULIN	ALM, PLM	Required	Kirszenblat et al., 2013
	efa-6	Arf Guanine Nucleotide Exchange Factor	ALM, PLM		Chen et al., 2011; Chen et al., 2015
	klp-7	Kinesin-13 family member	PLM	Inhibitor	Ghosh-Roy et al., 2012
	ccpp-6	Cytosolic carboxypeptidase	PLM	Required	Ghosh-Roy et al., 2012
	ttll-5	Putative tubulin polyglutamylase	PLM	Inhibitor	Ghosh-Roy et al., 2012
	zyg-8	Doublecortin-like-kinase	ALM, PLM	Required	Chen et al., 2015
	tac-1	Transforming-acidic-coiled-coil protein	ALM, PLM	Required	Chen et al., 2015
	ptrn-1	Microtubule-binding protein	PLM	Required	Chuang et al., 2014
	ebp-1	Microtubule End Binding Protein	PLM		Chen, et al., 2011
Axon Guidance	sax-3	Robo receptor	PLM	Inhibitor	Chen, et al., 2011
	slt-1	Slit ligand	AVM, PLM	Inhibitor	Gabel, 2008, Chen, 2011
	vab-1	Eph Receptor Tyrosine Kinase	PLM	Inhibitor	Wu et al., 2007
	unc-6	Netrin	AVM	Inhibitor	Gabel et al., 2008
	cwn-2	Wnt ligand	PLM	Required	Chen, et al., 2011
Actin Dynamics	unc-34	EVH1 domain-containing protein	AVM	Required	Gabel et al., 2008
	mig-10	Lamellopodin homolog	AVM	Inhibitor	Gabel et al., 2008
	ced-10	Rac	AVM	Required	Gabel et al., 2008
Ageing	daf-2	Insulin receptor	GABA	Inhibitor	Byrne et al., 2014
	daf-16	FOXO transcription factor	GABA	Required	Byrne et al., 2014
PTEN Signaling	daf-18	Phosphatase and tensin homolog	GABA	Inhibitor	Byrne et al., 2014
Developmental Switch	let-7	microRNA	AVM	Inhibitor	Zou et al., 2013
	lin-41	Ring finger-B box-Coiled coil	AVM	Required	Zou et al., 2013
	lin-29	Zinc finger transcription factor	AVM	Inhibitor	Zou et al., 2013
	alg-1	Argonaute	AVM	Inhibitor	Zou et al., 2013
Notch Signaling	lin-12	Notch	GABA	Inhibitor	el Bejjani, et al., 2012
	sup-17	ADAM protein	GABA	Inhibitor	el Bejjani, et al., 2012
	sel-12	Presenilin	GABA	Inhibitor	el Bejjani, et al., 2012
	hop-1	Presenilin	GABA	Inhibitor	el Bejjani, et al., 2012
Extracellular Matrix	sdn-1	Syndecan	Gaba	Required	Edwards et al., 2011
	pxn-2	Peroxidasin	PLM, ALM	Inhibitor	Gotenstein et al., 2010
Caspases	ced-3	Caspase	ALM	Required	Pinan-Lucarre, et al., 2012
	ced-4	Caspase activator	ALM	Required	Pinan-Lucarre, et al., 2012
RNA ligase	rtcb-1	RNA ligase	GABA	Inhibitor	Kosmaczewski et al., 2015
S6 Kinase Signaling	rsks-1	S6 kinase	PLM, ALM	Inhibitor	Hubert et al., 2014
	aak-2	AMP kinase	PLM	Required	Hubert et al., 2014
Serotonin Signaling	tph-1	tryptophan hydroxylase	PLM, GABA	Required	Alam et al., 2016
	hif-1	hypoxia-induced factor	GABA, PLM	Required	Alam et al., 2016
	ser-7	5-HT receptor	GABA	Required	Alam et al., 2016
	gpa-12	G protein alpha subunit	GABA	Required	Alam et al., 2016
	rhgf-1	RhoGEF	GABA	Required	Alam et al., 2016
	rho-1	RhoGTPase	GABA	Required	Alam et al., 2016
	rga-5	RhoGAP	GABA	Inhibitor	Alam et al., 2016
DLK-Independent Regeneration	egl-19	Voltage gated calcium channel subunit	ASJ	Inhibitor	Chung et al., 2016
	tax-4	Cyclic nucleotide-gated channel subunit	ASJ	Inhibitor	Chung et al., 2016
	tax-2	Cyclic nucleotide-gated channel beta subunit	ASJ	Inhibitor	Chung et al., 2016
	osm-6	Intraflagellar transport particle component	ASJ	Inhibitor	Chung et al., 2016
	unc-36	Alpha2/delta subunit of a voltage-gated calcium channel	ASJ	Inhibitor	Chung et al., 2016
	daf-11	Transmembrane guanylate cyclase	ASJ	Inhibitor	Chung et al., 2016
	sax-1	Ndr kinase	ASJ	Inhibitor	Chung et al., 2016
	unc-43	Type II calcium/calmodulin-dependent protein kinase	ASJ, ALM	Inhibitor	Chung et al., 2016