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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Mol Cancer Ther. 2016 Oct 7;15(12):2863–2874. doi: 10.1158/1535-7163.MCT-16-0515

Figure 2. Effect of treatment with fisetin, cabazitaxel and their combination on markers of proliferation and apoptosis.

Figure 2

A–C. Representative blots showing the effect of fisetin (20 μM), cabazitaxel (5nM) and the combination (fisetin 20 μM and cabazitaxel 5nM) treatment on, cleavage of PARP, BAX, Mcl-1 and PCNA proteins respectively in 22Rν1cells. Data are shown as representative of three independent experiments. GAPDH served as a loading control. Intensities of the bands were measured using densitometry and values first normalized to respective GAPDH and then reported below each gel as relative to control. Data are shown as a mean ± and SD of at least three independent experiments performed in triplicate; *, p ≤ 0.05**, p ≤ 0.005, ***, p ≤ 0.0005.