At the end of study, tumors were harvested from mice, subjected to IHC for proliferation (anti-ki67 and anti-PCNA); metastasis (anti-MMP-9); angiogenesis (anti-CD31) and (anti-VEGF). Left, representative photomicrographs of Ki67, PCNA, MMP-9, CD31 and VEGF-stained tumor section (x 40). Right, quantitation of Ki67, PCNA, MMP-9, CD31 and VEGF; **, p ≤ 0.02, ***, p ≤ 0.001.