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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Mol Cancer Res. 2016 Sep 21;14(12):1277–1287. doi: 10.1158/1541-7786.MCR-16-0251

Figure 2. Spn is differentially expressed in GBM cell lines and human tumor samples.

Figure 2

(A, B); Lysates from six different human GBM cell lines (A) and 12 different resected primary human GBM samples (B) were immunoblotted with anti-Spn, anti-PP1 or anti-Actin antibodies. (C, D); Formalin fixed paraffin embedded sections from non-neoplastic human brain (C) or three different GBM samples (D) were stained with H&E (upper panels) or anti-Spn antibodies (lower panels). Note that Spn protein is diffusely expressed in normal brain tissue. Spn is also expressed in GBM cells, but is largely absent in blood vessels within the tumor microenvironment. Scale bar, 50 μm.