Table 2.
Average (mean ± SD) full blood count and platelets during treatment of the rats with NVP, INH, and PAR over the study period.
| Group | RCC (×1012/l) | Hb (g/dl) | Hct (l/l) | MCV (fl) | MCH (pg) | MCHC (g/dl) | Plt (×109/l) | WCC (×109/l) | Neu (×109/l) | Ly (×109/l) | Mo (×109/l) | Eos (×109/l) | Bas (×109/l) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Untreated | |||||||||||||
| 0 days | 6.28 ± 0.2 | 12.9 ± 0.3 | 0.398 ± 0.01 | 63.5 ± 2.5 | 20.5 ± 0.4 | 32.3 ± 0.8 | 860 ± 221.1 | 6.95 ± 2.7 | 0.77 ± 0.2 | 4.67 ± 1.8 | 0.19 ± 0.1 | 0.02 ± 0.0 | 0.01 ± 0.0 |
| S | |||||||||||||
| 2 days | 6.67 ± 0.2 | 13.7 ± 0.1 | 0.422 ± 0.01 | 63.3 ± 2.3 | 20.6 ± 0.6 | 32.4 ± 0.6 | 849 ± 81.6 | 6.50 ± 0.9 | 0.60 ± 0.2 | 5.18 ± 0.7 | 0.21 ± 0.0 | 0.50 ± 0.2 | 0.01 ± 0.0 |
| 7 days | 7.53 ± 0.9 | 15.3 ± 1.7 | 0.451 ± 0.04 | 60.1 ± 2.5 | 20.3 ± 0.2 | 33.9 ± 1.2 | 1033 ± 79.8 | 5.44 ± 2.4 | 1.03 ± 0.8 | 4.07 ± 2.0 | 0.30 ± 0.3 | 0.04 ± 0.0 | 0.01 ± 0.0 |
| 14 days | 6.77 ± 0.6 | 13.9 ± 1.1 | 0.417 ± 0.03 | 61.8 ± 2.8 | 20.5 ± 0.6 | 33.2 ± 0.6 | 721 ± 196.4 | 5.22 ± 1.2 | 0.63 ± 0.5 | 4.21 ± 0.7 | 0.18 ± 0.1 | 0.18 ± 0.1 | 0.05 ± 0.0 |
| 28 days | 7.07 ± 0.7 | 13.9 ± 1.3 | 0.390 ± 0.04 | 55.1 ± 1.0 | 19.7 ± 0.1 | 35.8 ± 0.6 | 961 ± 172.5 | 7.38 ± 1.0 | 0.91 ± 0.2 | 6.15 ± 0.8 | 0.24 ± 0.1 | 0.07 ± 0.0 | 0.01 ± 0.0 |
| 42 days | 6.93 ± 0.8 | 13.4 ± 1.8 | 0.374 ± 0.05 | 53.9 ± 1.0 | 19.3 ± 0.4 | 35.8 ± 0.2 | 839 ± 166.0 | 3.93 ± 0.3 | 0.54 ± 0.1 | 3.23 ± 0.3 | 0.11 ± 0.0 | 0.04 ± 0.0 | 0.01 ± 0.0 |
| NVP | |||||||||||||
| 2 days | 6.51 ± 0.2 | 13.6 ± 0.4 | 0.408 ± 0.01 | 62.7 ± 0.8 | 20.9 ± 0.1 | 33.2 ± 0.3 | 854 ± 209.3 | 3.48 ± 0.8 | 1.02 ± 0.1 | 1.88 ± 0.3 | 0.10 ± 0.0 | 0.48 ± 0.4 | 0.00 ± 0.0 |
| 7 days | 7.14 ± 0.3 | 14.2 ± 0.5 | 0.424 ± 0.02 | 59.5 ± 1.8 | 19.9 ± 0.6 | 33.5 ± 0.5 | 779 ± 141.3 | 5.54 ± 1.3 | 0.76 ± 0.3 | 3.81 ± 0.9 | 0.49 ± 0.2 | 0.48 ± 0.2 | 0.03 ± 0.0 |
| 14 days | 6.97 ± 0.3 | 13.9 ± 0.4 | 0.415 ± 0.01 | 59.5 ± 2.2 | 19.9 ± 0.6 | 33.5 ± 0.3 | 1013 ± 73.0 | 4.86 ± 0.7 | 1.08 ± 0.2 | 3.38 ± 0.4 | 0.37 ± 0.1 | 0.02 ± 0.0 | 0.01 ± 0.0 |
| 28 days | 7.36 ± 0.6 | 14.2 ± 1.1 | 0.404 ± 0.03 | 55.0 ± 0.7 | 19.3 ± 0.3 | 35.0 ± 0.6 | 876 ± 17.2 | 6.07 ± 0.6 | 1.09 ± 0.2 | 4.62 ± 0.7 | 0.28 ± 0.2 | 0.08 ± 0.1 | 0.01 ± 0.0 |
| 42 days | 7.73 ± 0.3 | 14.5 ± 0.3 | 0.405 ± 0.00 | 52.5 ± 2.3 | 18.8 ± 0.5 | 35.8 ± 0.8 | 1052 ± 115.6 | 5.42 ± 0.1 | 1.52 ± 0.6 | 3.52 ± 0.6 | 0.33 ± 0.0 | 0.04 ± 0.0 | 0.01 ± 0.0 |
| INH | |||||||||||||
| 2 days | 6.57 ± 0.3 | 13.4 ± 0.4 | 0.416 ± 0.01 | 63.4 ± 2.0 | 20.5 ± 0.3 | 32.3 ± 0.7 | 880 ± 54.5 | 5.86 ± 1.1 | 0.59 ± 0.0 | 5.02 ± 1.1 | 0.21 ± 0.1 | 0.03 ± 0.0 | 0.01 ± 0.0 |
| 7 days | 6.05 ± 0.6 | 12.7 ± 1.1 | 0.381 ± 0.04 | 63.0 ± 0.6 | 21.0 ± 0.2 | 33.3 ± 0.2 | 478 ± 19.1 | 5.98 ± 0.8 | 0.56 ± 0.1 | 5.10 ± 0.8 | 0.19 ± 0.1 | 0.04 ± 0.0 | 0.02 ± 0.0 |
| 14 days | 6.65 ± 0.6 | 9.8 ± 5.4 | 0.394 ± 0.04 | 59.2 ± 2.7 | 19.8 ± 0.6 | 33.4 ± 0.7 | 494 ± 50.2 | 5.78 ± 1.1 | 0.61 ± 0.1 | 4.91 ± 0.9 | 0.23 ± 0.1 | 0.03 ± 0.0 | 0.00 ± 0.0 |
| 28 days | 7.27 ± 0.4 | 14.3 ± 0.8 | 0.406 ± 0.02 | 55.9 ± 0.6 | 19.7 ± 0.1 | 35.3 ± 0.4 | 845 ± 116.0 | 5.44 ± 0.4 | 0.66 ± 0.1 | 4.56 ± 0.4 | 0.17 ± 0.1 | 0.04 ± 0.0 | 0.01 ± 0.0 |
| 42 days | 7.25 ± 0.7 | 13.9 ± 1.2 | 0.390 ± 0.04 | 53.8 ± 1.9 | 19.2 ± 0.4 | 35.6 ± 0.8 | 785 ± 152.7 | 5.11 ± 0.9 | 0.84 ± 0.1 | 4.05 ± 0.6 | 0.22 ± 0.0 | 0.07 ± 0.0 | 0.01 ± 0.0 |
| PAR | |||||||||||||
| 2 days | 6.77 ± 0.0 | 14.8 ± 0.0 | 0.461 ± 0.00 | 68.1 ± 0.0 | 21.9 ± 0.0 | 32.1 ± 0.0 | 419 ± 0.0 | 7.54 ± 0.0 | 0.75 ± 0.0 | 5.96 ± 0.0 | 0.37 ± 0.0 | 0.46 ± 0.0 | 0.01 ± 0.0 |
| 7 days | 6.75 ± 0.2 | 13.9 ± 0.1 | 0.426 ± 0.00 | 63.2 ± 2.4 | 20.7 ± 0.8 | 32.7 ± 0.1 | 807 ± 22.8 | 7.32 ± 0.8 | 0.80 ± 0.2 | 6.22 ± 0.8 | 0.23 ± 0.0 | 0.07 ± 0.0 | 0.01 ± 0.0 |
| 14 days | 6.66 ± 0.2 | 13.8 ± 0.3 | 0.411 ± 0.01 | 61.7 ± 0.5 | 20.7 ± 0.1 | 33.6 ± 0.4 | 834 ± 43.0 | 4.19 ± 0.4 | 0.55 ± 0.0 | 3.42 ± 0.6 | 0.09 ± 0.1 | 0.13 ± 0.2 | 0.00 ± 0.0 |
| 28 days | 7.10 ± 0.2 | 14.1 ± 0.2 | 0.397 ± 0.00 | 56.0 ± 2.2 | 19.8 ± 0.8 | 35.4 ± 0.4 | 880 ± 87.0 | 5.32 ± 1.2 | 0.88 ± 0.1 | 4.19 ± 1.1 | 0.21 ± 0.1 | 0.04 ± 0.0 | 0.01 ± 0.0 |
| 42 days | 7.33 ± 0.3 | 14.5 ± 0.3 | 0.401 ± 0.01 | 54.8 ± 1.8 | 19.8 ± 0.5 | 36.2 ± 0.3 | 961 ± 85.8 | 4.91 ± 0.3 | 0.80 ± 0.2 | 3.86 ± 0.4 | 0.20 ± 0.0 | 0.05 ± 0.0 | 0.01 ± 0.0 |
RCC: red cell count; Hb: haemoglobin; Hct: haematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular haemoglobin; MCHC: mean corpuscular haemoglobin concentration; Plt: platelets; WCC: white cell count; Neu: neutrophils; Ly: lymphocytes; Mo: monocytes; Eos: eosinophils; Bas: basophils, S: saline; INH: isoniazid; NVP: nevirapine; PAR: paracetamol; p ≤ 0.05.