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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: J Biol Rhythms. 2016 Feb 1;31(2):142–160. doi: 10.1177/0748730415627067

Figure 3. Circadian clock modulates recovery from the sedative effects of alcohol.

Figure 3

(A) The time necessary for 50% of the flies to exhibit the righting reflex following sedation in DD, means and SEMs plotted (ANOVA: F5, 66 = 29.67, p < 0.001). Columns with common letters indicate no significant differences between time points based upon Bonferroni post hoc analyses. (B, C, D) The complete recovery curves for CT 1 and 13, 5 and 7, and 9 and 21 are shown respectively. (E) The time necessary for 50% of the flies to regain the righting reflex following alcohol-induced sedation was significantly affected by time of day in LD cycles with flies at ZT 9 exhibiting significantly shorter recovery times (ANOVA: F5, 42 = 23.25, p < 0.0001). (F, G, H) The complete recovery curves for ZT 1 and 13, 5 and 7, and 9 and 21 are shown respectively.