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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Mol Cancer Res. 2016 Sep 7;14(12):1195–1203. doi: 10.1158/1541-7786.MCR-16-0108

Figure 5. Effect of olaparib, alone and combined with IR, on p21 reporter activity.

Figure 5

A) Heterozygous reporter mice were dosed with 50 mg/kg or 100 mg/kg olaparib and drug concentrations in plasma determined at various time-points thereafter (x ± SD, n = 3 mice). B & C) p21 reporter mice were treated in triplicate with 75 mg/kg olaparib or with vehicle 30 min prior to exposure to 0- or 1 Gy IR. Representative images of in situ β-gal activity in large intestines (B) and kidneys (C). Scale bar = 50 μm for large intestine micrographs. For kidney panoramic micrographs, scale bar = 1000 μm and 100 μm for all other kidney images.