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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Mol Cancer Res. 2016 Sep 7;14(12):1195–1203. doi: 10.1158/1541-7786.MCR-16-0108

Figure 6. Olaparib causes DNA damage in the mucosal lining of the large intestine.

Figure 6

A) The micrographs display γ-H2AX staining in the large intestines of three separate untreated wild-type mice (-olaparib), or three separate mice that were euthanized 4 h after treatment with 75 mg/kg olaparib. Scale-bar = 50 μm. B) A higher resolution image demonstrating the primarily focal nature of the γ-H2AX signal in large intestines of olaparib-treated wild-type mice. The arrow points to a cell displaying a more pan-nuclear γ-H2AX signal. Scale-bar = 10 μm.