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Mechanisms of ncRNA-mediated genome regulation. (A) Protein (orange and gray ovals)-sRNA (blue or red lines) interaction targets proteins to complementary sequences in trans. (B) Tethered ncRNAs form platforms for the assembly of regulatory protein complexes in cis. (C) ncRNAs facilitate protein-protein interactions by acting as a structural component of these complexes. (D) ncRNAs bridge or template the repair of double-strand breaks (DSBs).
