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Trp53bp2Δ3/Δ3 mice have neural tube defects. Strain dependence of NTD penetrance in Trp53bp2Δ3/Δ3 mice: Embryo phenotypes in pure C57BL/6 (left), mixed 129 Sv-C57BL/6 (middle), and BALB/c (right) background embryos range in severity from small exencephaly (right, white arrow) to severe craniorachischisis (left upper panel, white arrows). Spina bifida is also observed in the mixed (middle panels, white arrows) and B6 (left lower panel, white arrow) backgrounds
