Skip to main content
. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Infect Genet Evol. 2016 Aug 29;46:292–307. doi: 10.1016/j.meegid.2016.08.031

Figure 5.

Figure 5

Summary of integrase strand transfer inhibitor drug resistance mutations.

Bold/underline: High-level reduced susceptibility or virological response. Bold: reduced suceptibility or virological response. Plain text: reduced susceptibility in combination with other INSTI-resistance mutations. Asterisk: increased susceptibility. Abbreviations: raltegravir (RAL), elvitegravir (EVG), dolutegravir (DTG). Additional mutations: H51Y, L74M, T97A, S153YF, G163RK, S230R, and R263K are relatively nonpolymorphic INSTI-selected accessoryresistance mutations. E92GV, E138T, Y143KSGA, Q148N, and N155ST are unusual variants at the positions listed above. P145S and Q146P are rare EVG-resistance mutations. G118R and F121Y are rare nonpolymorphic INSTI resistance mutations. References: http://hivdb.stanford.edu/DR/INIResiNote.html.