Table 4.
Age group specific estimates for within individual and between individual variability in HCHS/SOL by age group
| Age Group: 18–44 y
|
Age Group: 45+ y
|
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | CVI | N | Mean (SD) | CVG | CV(P+A) | II | N | CVI | N | Mean (SD) | CVG | CV(P+A) | II | |
| LIVER ENZYME MEASURES | ||||||||||||||
| Alanine aminotransferase (U/l) | 25 | 23.3 | 333 | 25.6 (1.42) |
81.19 | 5.5 | 0.29 | 25 | 24.9 | 456 | 26.1 (1.76) |
63.93 | 6.7 | 0.4 |
| Aspartate aminotransferase (U/l) | 25 | 17.1 | 334 | 23.1 (1.59) |
48.66 | 6.9 | 0.38 | 25 | 11.4 | 453 | 24.4 (1.83) |
49.15 | 7.5 | 0.28 |
| GGT (U/l) | 24 | 18.8 | 332 | 29 (1.26) |
102.56 | 4.3 | 0.19 | 24 | 16.3 | 442 | 34 (2.73) |
90 | 8 | 0.2 |
| KIDNEY FUNCTION MEASURES | ||||||||||||||
| Cystatin C (mg/l) | 25 | 5.3 | 332 | 0.71 (0.03) |
18.47 | 3.6 | 0.35 | 24 | 5.1 | 438 | 0.84 (0.03) |
26.89 | 3.5 | 0.23 |
| Creatinine (mg/dl) | 24 | 7.5 | 338 | 0.81 (0.05) |
24.36 | 6.7 | 0.41 | 25 | 7 | 455 | 0.86 (0.06) |
46.37 | 6.5 | 0.21 |
| Urine creatinine, random (mg/dl) | 25 | 43.9 | 399 | 164 (6.09) |
53.59 | 3.7 | 0.82 | 26 | 38.7 | 519 | 133.5 (3.6) |
54.22 | 2.7 | 0.72 |
| Urine microalbumin, random (mg/dl) | 23 | 67.2 | 389 | 23 (2.66) |
353.52 | 11.6 | 0.19 | 21 | 38.2 | 490 | 34.6 (2.38) |
442.52 | 6.9 | 0.09 |
| Log Albumin/creatinine ratio (mg/g) | 24 | 29.4 | 390 | 1.9 (0.14) |
46.17 | 7.5 | 0.66 | 22 | 12.8 | 487 | 2.3 (0.08) |
48.25 | 3.6 | 0.27 |
| LIPID MEASURES | ||||||||||||||
| Total cholesterol (mg/dl) | 25 | 7.6 | 336 | 185.5 (5.73) |
19.97 | 3.1 | 0.41 | 26 | 6.1 | 451 | 207.1 (6.07) |
18.95 | 2.9 | 0.36 |
| Triglycerides (mg/dl) | 25 | 22.3 | 336 | 120.9 (4.5) |
72 | 3.7 | 0.31 | 26 | 18.4 | 453 | 143.6 (6.51) |
62.6 | 4.5 | 0.3 |
| HDL-cholesterol (mg/dl) | 25 | 8.5 | 334 | 49.3 (1.45) |
26.52 | 2.9 | 0.34 | 26 | 5.5 | 455 | 50.3 (1.68) |
25.12 | 3.3 | 0.26 |
| LDL-cholesterol (mg/dl) | 25 | 9.3 | 329 | 112 (4.49) |
26.93 | 4 | 0.37 | 26 | 10 | 439 | 127.8 (4.57) |
26.41 | 3.6 | 0.4 |
| DIABETES RELATED MEASURES | ||||||||||||||
| Insulin, fasting (mU/l) | 25 | 34.3 | 338 | 12.7 (1.7) |
64.64 | 134 | 0.57 | 25 | 22.2 | 429 | 13.1 (1.58) |
83.09 | 12 | 0.3 |
| Insulin, post OGTT (mU/l) | 21 | 33.5 | 479 | 70.9 (6.45) |
99.67 | 9.1 | 0.35 | 16 | 29.4 | 439 | 104.1 (7.91) |
88.93 | 7.6 | 0.34 |
| Glucose, fasting (mg/dl) | 24 | 3.4 | 343 | 97.9 (2.79) |
31.88 | 2.8 | 0.14 | 26 | 6.5 | 433 | 110.9 (2.95) |
37.88 | 2.7 | 0.18 |
| Glucose, post OGTT (mg/dl) | 21 | 23.8 | 486 | 108.3 (4.12) |
30.26 | 3.8 | 0.8 | 16 | 15.2 | 441 | 137.6 (4.06) |
36.06 | 3 | 0.43 |
| % Glycosylated Hemoglobin | 27 | 2 | 421 | 5.5 (0.05) |
16.62 | 0.9 | 0.14 | 30 | 2.4 | 505 | 6.1 (0.06) |
21.49 | 1 | 0.12 |
| IRON RELATED MEASURES | ||||||||||||||
| Ferritin (ug/l) | 24 | 20.2 | 325 | 95.9 (3.84) |
100.98 | 4 | 0.2 | 24 | 16.5 | 435 | 130.1 (6.99) |
96.21 | 5.4 | 0.18 |
| Iron (ug/dl) | 25 | 34.7 | 332 | 87.9 (2.66) |
38.59 | 3 | 0.9 | 25 | 23.5 | 451 | 88.7 (2.71) |
36.77 | 3.1 | 0.64 |
| Total Iron Binding Capacity (TIBC) (ug/dl) | 25 | 5.2 | 336 | 327.4 (10.62) |
14.94 | 3.2 | 0.41 | 26 | 4.9 | 453 | 318.9 (10.22) |
14.58 | 3.2 | 0.4 |
| % Transferrin saturation | 25 | 35.1 | 333 | 27.7 (0.72) |
42.94 | 2.6 | 0.82 | 25 | 29 | 452 | 28.7 (0.78) |
40.62 | 2.7 | 0.72 |
| INFLAMMATION MEASURES | ||||||||||||||
| High-sensitivity C-Reactive Protein (mg/l) | 24 | 26.1 | 335 | 3.2 (0.16) |
125.86 | 5.1 | 0.21 | 25 | 58.6 | 453 | 4.2 (0.19) |
138.4 | 4.5 | 0.42 |
| HEMATOLOGICAL MEASURES | ||||||||||||||
| Red Blood Count (×10e12) | 26 | 2.8 | 421 | 4.8 (0.08) |
8.42 | 1.7 | 0.39 | 30 | 2.3 | 500 | 4.7 (0.08) |
8.84 | 1.7 | 0.33 |
| White Blood Count (×10e9) | 24 | 12.5 | 385 | 6.4 (0.36) |
27.23 | 5.5 | 0.5 | 29 | 11 | 454 | 6.5 (0.36) |
29.84 | 5.6 | 0.41 |
| Platelet Count (×10e9) | 26 | 6.7 | 421 | 255.5 (9.28) |
24.87 | 3.6 | 0.31 | 30 | 7.3 | 496 | 248.3 (9.35) |
27.04 | 3.8 | 0.3 |
| Hemoglobin (g/dl) | 26 | 3.2 | 420 | 13.8 (0.26) |
10.82 | 1.9 | 0.34 | 30 | 2.7 | 500 | 13.6 (0.24) |
10.21 | 1.8 | 0.32 |
| % Hematocrit | 26 | 3.3 | 419 | 41.9 (0.8) |
9.41 | 1.9 | 0.41 | 30 | 3.4 | 501 | 41.6 (0.77) |
8.94 | 1.9 | 0.43 |
| Mean Corpuscular Volume (fl) | 25 | 2.1 | 420 | 88.3 (0.61) |
6.13 | 0.7 | 0.37 | 28 | 1.3 | 499 | 89.4 (0.6) |
6.68 | 0.7 | 0.21 |
| Mean Corpuscular Hemoglobin (pg) | 25 | 1.2 | 421 | 29.1 (0.29) |
7.12 | 1 | 0.21 | 30 | 1.2 | 500 | 29.1 (0.27) |
7.04 | 0.9 | 0.21 |
| Mean Corpuscular Hemoglobin Concentration (g/dl) | 25 | 2.4 | 420 | 33 (0.38) |
4.12 | 1.1 | 0.66 | 29 | 2.1 | 501 | 32.7 (0.33) |
4.24 | 1 | 0.55 |
| % Red Cell Distribution Width | 26 | 3.2 | 423 | 13.5 (0.11) |
9.02 | 0.8 | 0.37 | 29 | 2.1 | 499 | 13.8 (0.09) |
9.07 | 0.6 | 0.24 |
| % Neutrophils | 24 | 10.2 | 382 | 55.4 (2.71) |
18.21 | 4.9 | 0.62 | 30 | 14.3 | 451 | 53.9 (3.84) |
20.1 | 7.1 | 0.8 |
| % Lymphocytes | 24 | 16.7 | 385 | 33.1 (2.32) |
24.42 | 7 | 0.74 | 30 | 18.3 | 451 | 34 (3.28) |
26.18 | 9.6 | 0.79 |
| % Monocytes | 23 | 9 | 385 | 8.1 (0.96) |
26.47 | 12 | 0.57 | 29 | 21.1 | 450 | 8.1 (1.06) |
28.38 | 13.2 | 0.88 |
| % Eosinophils | 24 | 28 | 387 | 2.8 (0.53) |
92.67 | 18.6 | 0.36 | 29 | 37.7 | 451 | 3 (0.52) | 93.66 | 17.3 | 0.44 |
| % Basophils | 24 | 66.4 | 385 | 0.5 (0.36) |
79.72 | 75.7 | 1.26 | 30 | 75.2 | 452 | 0.6 (0.4) | 79.33 | 67.8 | 1.28 |
| Neutrophil Count (×10e9) | 23 | 14.6 | 382 | 3.6 (0.32) |
39.32 | 8.7 | 0.43 | 29 | 18.7 | 450 | 3.6 (0.37) |
39.76 | 10.5 | 0.54 |
| Lymphocyte Count (×10e9) | 23 | 12.6 | 384 | 2.1 (0.14) |
26.05 | 6.9 | 0.55 | 29 | 11.9 | 445 | 2.1 (0.16) |
29.65 | 7.7 | 0.48 |
| Monocyte Count (×10e9) | 23 | 17.4 | 387 | 0.5 (0.07) |
30.3 | 13.1 | 0.72 | 29 | 15.6 | 457 | 0.5 (0.08) |
33.54 | 14.6 | 0.64 |
| Eosinophil Count (×10e9) | 24 | 28.8 | 389 | 0.2 (0.04) |
96.31 | 20.8 | 0.37 | 29 | 26.5 | 456 | 0.2 (0.04) |
104.13 | 19.2 | 0.31 |
| Basophil Count (×10e9) | 24 | 119.2 | 388 | 0 (0.03) | 156.76 | 131.3 | 1.13 | 30 | 133.2 | 452 | 0 (0.03) | 137.93 | 126.9 | 1.33 |
CVI = coefficient of variation for within-individual variability
CVG = coefficient of variation for between-individual variability. Mean values of the blinded duplicate
CV(c+m) = coefficient of variation for process and analytical variability
II is the Index of Individuality