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. Author manuscript; available in PMC: 2018 May 15.
Published in final edited form as: Biol Psychiatry. 2016 Jun 4;81(10):862–873. doi: 10.1016/j.biopsych.2016.05.022

Figure 3.

Figure 3

Postnatal development of DLPFC layer 3 pyramidal cells. (A) Age-related alterations in mean spine density on dendrites of layer 3 pyramidal cells in monkey DLPFC (x-axis in weeks). Gray bar indicates the peripubertal period in monkeys that is roughly analogous to adolescence in humans (93;119). Adapted from (91). (B) Age-related increase in AMPA relative to NMDA receptor contribution to excitatory postsynaptic currents (EPSCs) in DLPFC layer 3 pyramidal cells (x-axis in months). Adapted from (96). (C and D) Age-related changes in mRNA expression of molecular determinants of glutamate neurotransmission (AMPA receptor subunit GluR1 and NMDA receptor subunit GluN1) in DLPFC layer 3 pyramidal cells (x-axis in months). Adapted from (97). In panels B-D, age groups not sharing the same letter are significantly different (p<0.05).