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. Author manuscript; available in PMC: 2018 May 15.
Published in final edited form as: Biol Psychiatry. 2016 Jun 4;81(10):862–873. doi: 10.1016/j.biopsych.2016.05.022

Table 1.

DLPFC circuitry: Cell type-specific functions, alterations in schizophrenia and developmental trajectories

Proposed circuit function in working memory Alterations in schizophrenia Postnatal developmental trajectories References
Pyramidal Neurons Recurrent excitation among layer 3 pyramidal neurons ↓ Dendritic spine density
↓ Somal and dendritic arbor size
↓ GABAA α1 mRNA
↑ GABAA α2-IR AIS; ↑ GABAA α2 mRNA		 ↑ Perinatal dendritic spine density
↓ Peripubertal dendritic spine density
↑ GABAA α1 mRNA
↓ GABAA α2 mRNA		 (57–59), (91–93)
(54–56), (91–93)
(75;76;135;136)
(75;137)
PVBCs Feedback inhibition of layer 3 pyramidal neurons ↑ “OR mRNA
↓ PV mRNA and protein		 ↓ “OR mRNA
↑ PV protein levels per terminal
↔ Terminal density during postnatal development		 (138)
(72;74;139)
(100)
PVChCs Regulation of pyramidal neurons:
-Blockade of back- propagating action potentials
-Depolarization		 ↓ GAT1 immunoreactive cartridge terminals
? PV protein levels in PVChC terminals currently unknown		 ↓ Terminal density during postnatal development
↔ PV protein levels per terminal		 (100;137)
(100)