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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Matrix Biol. 2016 Jun 4;60-61:96–109. doi: 10.1016/j.matbio.2016.06.001

Figure 2.

Figure 2

(a) Biomaterial-mediated regeneration. Upon injury, quiescent muscle satellite cells are delivered within a biomaterial. Biomaterial encapsulation provides initial protection of the transplanted cells from inflammation. (b) Biomaterial promotes cell survival by providing integrin attachment sites. Donor cells within the biomaterial activate, self-renew, proliferate, migrate, and differentiate to induce host muscle regeneration. Encapsulated growth factor is released in a controlled manner, as the biomaterial is degraded by the cell-secreted proteases.