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. 2016 Dec 5;7:541. doi: 10.3389/fphys.2016.00541

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Copyright © 2016 de Melo, Vieira, Antônio, dos Santos, Portes, Feliciano, de Oliveira, Silva, de Carvalho, Tucci and Serra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exercise training modulates key components of the survival and mitochondrial apoptosis pathway in the RV myocardial on PAS. It is remarkable that activated form of Akt₁ (A: SHAM, n = 8; SS, n = 8; TS, n = 7) and anti-apoptotic Bcl-xL (B: SHAM, n = 8; SS, n = 6; TS, n = 7) were significantly up-regulated in the exercise animals. Moreover, a beneficial effect of exercise was observed for cleaved caspase-3 protein (B), in which indicates a myocardial apoptosis normalization. ^#p < 0.05 vs. SHAM group. ^&p < 0.01 vs. SS group.