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. 2016 Dec 5;10:279. doi: 10.3389/fncel.2016.00279

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Copyright © 2016 Savchenko, Malm, Konttinen, Hämäläinen, Guerrero-Toro, Wojciechowski, Giniatullin, Koistinaho and Magga.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Monocytic cells retain their viability and phagocytic activity within native Aβ deposits ex vivo. The incubation of monocytic cells with native Aβ deposits in hippocampal sections obtained from aged APdE9 mice did not affect cell viability (A, n = 8). Monocytic cells also retained their characteristics as phagocytes since no difference in the percentage of CD68⁺ expressing cells (B, n = 6) or the expression level of CD68 (mean fluorescent intensity (MFI)) in single cells were observed (C, n = 6). This was analyzed by flow cytometry after collecting the cells incubated on top of control (wt) and native Aβ (APdE9) mouse hippocampal sections (D). Monocytic cells phagocytosed both diffuse and hard Aβ plaques (E). Monocytic cells gathered around vascular Aβ plaques but were not observed to phagocytose them despite of high cell concentration (F). Scale bar 20 μm (F), 500 μm (E).