Figure 3.

Population pharmacokinetic parameters used for the simulations: volume of distribution (Vd) of central compartment = 376 mL/kg, Vd of peripheral compartment = 298 mL/kg, clearance (CL) from central compartment = 1.84 mg/(kg × min), CL from peripheral compartment = 21 mL/(kg × min), and effect of PB presence on CL = 1.73. (A) Simulations of plasma concentration–time profiles following 5-min infusions of different doses in a dog not on enzyme-inducing co-medications. Here, the desired range is represented by the black dashed lines, and the black vertical line denotes 30 min post-dose. (B) Simulations of plasma concentration–time profiles following 5-min infusions of different doses in a dog on enzyme-inducing co-medications. Here, the desired range is represented by the black dashed lines, and the black vertical line denotes 30 min post-dose.