Table 2.
Effect of oral administration of different doses of SEP, LEP, LOP, and SOP extracts in vivo.
| Group | Dose (mg/kg) |
Granuloma number | Granuloma diameter (GD) | Eggs in liver tissue | Immunohistochemical findings | |||
|---|---|---|---|---|---|---|---|---|
| Mean ± SE | Reduction% | Mean (μm) ± SE | Reduction% | iNos hepatocytes | iNos inflammatory cells | |||
| SEP (G5&G7) |
600 | 51.2∗∗ | 57.8 | 141.2 ± 22.1∗∗ | 40.1 | Absent | Weakest | Negative |
| 800 | 45.3∗∗ | 62.7 | 139.2 ± 24.5∗∗ | 40.9 | Absent | Weakest | Negative | |
|
| ||||||||
| LEP (G4&G6) |
600 | 59.1∗ | 51.3 | 154.3 ± 11.2∗∗ | 34.5 | Numerous | Strong | Strong |
| 800 | 55.7∗∗ | 54.1 | 148.1 ± 22.1∗∗ | 37.2 | Absent | Weak | Weak | |
|
| ||||||||
| LOP (G8&G10) |
600 | 63.2∗ | 47.9 | 168.1 ± 22.1∗ | 28.7 | Numerous | Strong | Strong |
| 800 | 60.8∗ | 49.9 | 164.5 ± 21.2 | 30.2 | Few | Weak | Strong | |
|
| ||||||||
| SOP (9&G11) |
600 | 68.2∗ | 43.8 | 189.4 ± 24.5∗ | 19.6 | Numerous | Strong | Strong |
| 800 | 57.3∗∗ | 52.8 | 176.2 ± 25.1∗ | 25.2 | Few | Strong | Strong | |
|
| ||||||||
| PZQ(G3) | 200 | 39.4∗ | 67.6 | 135.4 ± 20.3 | 42.5 | Absent | Weakest | Negative |
|
| ||||||||
| Infected untreated controls (G1&G2) | 121.3 | — | 235.7 ± 16.1 | — | Numerous | Strong | Strong | |
The difference was significant at ∗ P < 0.01 and ∗∗ P < 0.001 compared to infected untreated control group.