. 2016 Nov 24;10(2):306. doi: 10.4081/oncol.2016.306

Table 1.

Arteriole and sinusoid vesselfactors involved in hematopoiesis regulation.

Factor	Function
Factor	Chro.	Normal BM	Leukemia	References
VEGFR-2	4q12	Recovery and reconstitution of HSCs	Up regulation.	29-31
			AKT phosphorylation.
			Apoptosis inhibition.
			Induces drugresistance.
SCF	12q22	Maintenance of HSCs	Up regulation.	32-35
SCF	12q22	Maintenance of HSCs	Leukemic cells growth.	32-35
E-selectin	1q24-25	Promotesthe proliferation of HSCs	Survival of leukemic cells.	36-38
E-selectin	1q24-25	Promotesthe proliferation of HSCs	Migration of leukemic cells to another location	36-38
NO	7q35-36	Differentiation to myeloid progenitors	Induces apoptosis in leukemia cells.	39-41
CXCL-12	10q11	Maintenance of HSCs	Up regulation.	42-45
CXCL-12	10q11	Maintenance of HSCs	Survival and proliferation of leukemia cells	42-45
DLL1,4 (Notch ligand)	6q27 15q21.1	Expansion and exhaustionprevention of HSCs	Unfavorable prognosis.	46-49
Jagged-1	20p12	Regenerative of HSCs	Up regulation.	50-52
Jagged-1	20p12	Regenerative of HSCs	Favorable prognosis.	50-52
Pleiotrophin	7q33	Expansion and retention of HSCs	Up regulation.	53-55
Pleiotrophin	7q33	Expansion and retention of HSCs	Poor prognosis.	53-55

VEGFR-2, vascular endothelial growth factor-2; HSC, hematopoietic stem cell; SCF, stem cell factor; E-selectin, endothelial selectin; CXCL-12, C-X-C motif chemokine 12; NO, nitric oxide; DLL, delta-like ligand.