Table 1.
Role of different types of lamins in various types of cancers.
| Type of cancer | Type of lamins involved | Phenotype of lamin | Changes in nuclear shape/size |
|---|---|---|---|
| Hepatocellular carcinoma | Lamin B | Increased expression of LaminB | Enlargement of nucleus |
| Increased expression of Lamin B in Plasma | |||
| Prostate cancer | Lamin | Increased expressionof lamin B | Enlargement of nucleus |
| BCC | LaminA/C | Low expression of LaminA/C | Enlargement of nucleus |
| Colon cancer (Later stages) | LaminA/C | Low expression of LaminA/C | Enlargement of nucleus |
| Gastrointestinal Neoplasms | LaminA/C | Aberrant or decreased LaminA/C expression | Enlargement of nucleus |
| Gastric carcinoma | LaminA/C | Decreased LaminA/C mRNA and protein expression | Enlargement of nucleus |
| Breast cancer | LaminA/C | Decreased LaminA/C expression | Enlargement of nucleus |
| Neuroblastoma | LaminA/C | Decreased LaminA/C expression | Enlargement of nucleus |