Figure 2. Annotation of EV-enriched protein coding RNA transcripts using UniProt and GO databases.
(A) Canonical transcripts. (B) Isoform transcripts. (C) Missing protein transcripts (i.e., protein annotations seen in Ensembl but not UniProtKB). Ensembl/GENCODE analysis further categorized EV-enriched mRNAs (relative to CL) into protein coding (left), and those predicted to be targets of nonsense-mediated decay (middle) and non-stop decay (right). DAVID Bioinformatics Resource was used to annotate biological process GO for EV-enriched transcripts common to all EV subtypes and mRNAs encoding (D) canonical and (E) isoform proteins selectively distributed into EV subtypes.
