Table 5. Stepwise backwards multivariate regression modelling for associations with 90 days’ bad functional outcome.
| Model 5A | |||
|---|---|---|---|
| Final model: First Step | Mixed OR | 95% CI | P > |z| |
| Model characteristics: n = 92; dof = 8; AIC = 109.27; BIC = 129.44; Sensitivity = 71.79%; Specificity = 79.25%; PPV = 71.79%; NPV = 79.25%; Overall rate of classification = 76.09%; ROC area = 0.8036; Pseudo R2 = 0.2562 | |||
| Delayed-LCVF | 0.91 | 0.24, 3.38 | 0.884 |
| NIHSS at admission | 1.02 | 0.93, 1.13 | 0.624 |
| Acute Core volume (in mL) | 1.02 | 0.999, 1.05 | 0.058 |
| Penumbra volume (in mL) | 0.999 | 0.99, 1.01 | 0.969 |
| Clot location | 0.4991 | ||
| Proximal thrombus | 0.64 | 0.17, 2.37 | 0.499 |
| Distal thrombus | 1 [Ref] | ||
| Reperfusion status | 0.0001* | ||
| Poor reperfusion | 9.05 | 2.92, 28.05 | <0.0001* |
| Major reperfusion | 1 [Ref] | ||
| Dyslipidaemia | 1.03 | 0.35, 2.97 | 0.961 |
| Model 5B | |||
| Reduced Model without delayed-LCVF | Mixed OR | 95% CI | P > |z| |
| Model characteristics: n = 92; dof = 5; AIC = 103.2977; BIC = 115.91; Sensitivity = 69.23%; Specificity = 79.25%; PPV = 71.05%; NPV = 77.78%; Overall rate of classification = 75%; ROC area = 0.8021; Pseudo R2 = 0.2560 | |||
| NIHSS at admission | 1.02 | 0.93, 1.12 | 0.612 |
| Acute Core volume (in mL) | 1.02 | 0.999, 1.046 | 0.051 |
| Clot location | 0.3677 | ||
| Proximal thrombus | 0.61 | 0.21, 1.78 | 0.368 |
| Distal thrombus | 1 [Ref] | ||
| Reperfusion status | 0.0001* | ||
| Poor reperfusion | 8.82 | 3.01, 25.86 | <0.0001* |
| Major reperfusion | |||
| Model 5C | |||
| Reduced model with delayed-LCVF:Last Step | Mixed OR | 95% CI | P > |z| |
| Model characteristics: n = 92; dof = 7; AIC = 74.83; BIC = 92.49; Sensitivity = 82.05%; Specificity = 88.68%; PPV = 84.21%; NPV = 87.04%; Overall rate of classification = 85.87%; ROC area = 0.93; Pseudo R2 = 0.5149 | |||
| Delayed-LCVF | 0.90 | 0.25, 3.27 | 0.875 |
| NIHSS at admission | 1.02 | 0.93, 1.12 | 0.618 |
| Acute Core volume (in mL) | 1.02 | 0.999, 1.05 | 0.051 |
| Clot location | 0.4891 | ||
| Proximal thrombus | 0.64 | 0.18, 2.24 | 0.489 |
| Distal thrombus | 1 [Ref] | ||
| Reperfusion status | 0.0001* | ||
| Poor reperfusion | 9.05 | 2.94, 27.83 | <0.0001* |
| Major reperfusion | 1 [Ref] | ||
1Used as reference category.
P < 0.1 for enter and stay criteria. The two multivariate models differed in terms of the particular covariates/factors included. *P < 0.05 as the threshold for statistical significance.
Abbreviations: dof = degrees of freedom; OR = Odds Ratio; AIC and BIC = Akaike and Bayesian information criteria; PPV = Positive predictive value; NPV = Negative predictive value; ROC: Receiver-operator characteristic curve; CI = Confidence interval; TPME =Time to peak of maximum arterial enhancement (in seconds); LCVF = Late venous phase cortical vein filling; NIHSS = National Institute of Health Stroke Scale Score.