Figure 2. Simulation of the optical acceleration of DNA hybridization with probe AuNPs by the Light-induced Molecular Recognition Metropolis Method (LMRM).
(a) Model for calculation: the total number of Monte Carlo steps is 106. Final configurations for (b) complementary and (c) mismatched DNA (see also Supplementary movies S1 and S2). In (b,c) the wavelength was 1,064 nm, diameter of laser spot 1 μm, AuNP diameter 30 nm, and input power 50 mW at the focused area. (d) Calculated extinction spectra of assembled NPs with complementary DNA or mismatched DNA for different complementarity related with binding energies. The vertical dashed line indicates the initial LSP peak position, and the red arrow indicates the peak shift under light-induced hybridization depending on εhbp.