Table 3. Prognostic biomarkers in tissues for hepatocellular carcinoma.
Reported ID | Offical ID | Sample | Ethnicity | Features | Expression | PMID | Validated Targets |
---|---|---|---|---|---|---|---|
miR-101 | miR-101-3p | 20 HC 25 HBV-HCC | China | 1.HBsAg, HBV DNA level and tumor size | up | 24260081112 | NA |
miR-101 | miR-101-3p | 130 HCC | China | tumor suppressor | down | 2317871399 | SOX9 |
miR-101 | miR-101-3p | 30 HC 79 CHB 61 HBV-LC 67 HBV-HCC | China | 1.inhibit HCC cell proliferation2.tumor suppressor | up | 2497195338 | NA |
miR-106b | miR-106b-5p | 104 HCC | China | 1.tumor size2. vascular invasion3. proliferation4. anchorage-independent growth of HCC cells5.metastasis | up | 2546644964 | NA |
miR-122 | miR-122-5p | 60 HCC | China | 1.tumor suppressor2.maintenance of normal physiological metabolism | down | 26252254100 | PKM2 |
miR-125b | miR-125b-5p | 49 HCC | China | tumor suppressor | down | 24811246101 | Eif5a2 |
miR-1269 | miR-1269a | 95 HCC | China | 1.tumor nodes2.portal vein tumor embolus3.vaso-invasion4.tumor capsular infiltration5.expression of MTDH6.onco-miR7.carcinogenesis, metastasis and invasion of HCC | up | 2578504872 | AGAP1, AGK, BPTF, C16orf74, DACT1, LIX1L, RBMS3, ZNF706 and BMPER |
miR-128-3p | miR-128-3p | 72 HCC | China | 1.suppress proliferation2.suppress metastasis | down | 2596236073 | PIK3R1 PI3K/AKT |
miR-130a | miR-130a-3p | 102 HCC | China | 1.gender, HBsAgstatus, tumor size, and TNM stage2.tumor suppressor | down | 25218269102 | NA |
miR-137 | miR-137 | 136 HCC | China | 1.vein invasion2.distant metastasis3.inhibition promotes HCC cell growth | down | 2497080835 | AKT2 |
miR-146a | miR-146a-5p | 85 HCC | China | tumor suppressor | down | 24172202103 | ROCK1 |
miR-155 | miR-155-5p | 100 HCC | China | 1.metastasis2.inhibits apoptosis | up | 2386366945 | NA |
miR-155 | miR-155-5p | 216 HCC | China | onco-miR | up | 22629365108 | NA |
miR-17-5p | miR-17-5p | 120 HCC | China | regulating proliferation and migration | up | 2258301165 | p38 MAPK-HSP27 |
miR-182 | miR-182-5p | 81 HCC | China | 1.onco-miR2.motility and invasiveness | up | 2581340366 | FOXO1 |
miR-182 | miR-182-5p | 86 HCC | China | intrahepatic metastasis | up | 2268171767 | MTSS1 |
miR-183 | miR-183-5p | 81 HCC | China | 1.onco-miR2.motility and invasiveness | up | 2581340366 | FOXO1 |
miR-185 | miR-185-5p | 41 NTR 54 TR | China | 1.suppress the tumor cell growth2.suppress invasive | down | 2364805436 | NA |
miR-188-5p | miR-188-5p | 250 HCC | China | 1.suppress tumor cell proliferation2.suppress metastasis | down | 2599816374 | FGF5 |
miR-18b | miR-18b-5p | 110 HCC | Japan | 1.proliferation2.loss of cell adhesion ability | up | 2349690152 | TNRC6B |
miR-199a-5p | miR-199a-5p | 120 HCC | China | 1.Negatively Associated With Malignancies2.Regulates Glycolysis3.Lactate Production | down | 26054020145 | Hexokinase 2 |
miR-206 | miR-206 | 147 HCC | China | 1.suppresses cell proliferation2.promotes apoptosis. | down | 2551308646 | NA |
miR-21 | miR-21-5p | 50 HC 30 CH 136 HCC | Japan | NA | down | 21749846110 | NA |
miR-21 | miR-21-5p | 112 HCC | China | 1.tumor differentiation2.TNM stage3.vein invasion | up | 2626162068 | NA |
miR-21 | miR-21-5p | 119 HCC | China | 1.tumorinvasion, metastasis and prognosis2.promote cell proliferation and invasion3.inhibits cell apoptosis | up | 2515037347 | NA |
miR-21 | miR-21-5p | 74 ICC | China | intrahepatic cholangiocarcinoma proliferation and growth | up | 2580322956 | PTPN14 and PTEN |
miR-212 | miR-212-3p | 86 HCC | China | 1.inhibited cell proliferation2.induced apoptosis | down | 2634732148 | FOXA1 |
miR-214 | miR-214-3p | 65 HCC | China | tumor suppressor | down | 23962428104 | FGFR-1 |
miR-25 | miR-25-3p | 96 HCC | Iran | 1.TNM stage2.suppress proliferation3.suppress migration | up | 2620929669 | NA |
miR-26a | miR-26a-5p | 120 HCC | China | 1.Cell Cycle2.angiogenesis | up | 2425942684 | CDK6, cyclin D1 |
miR-26a | miR-26a-5p | 130 HCC | China | 1.suppress the tumor cell growth2.suppress invasive | down | 2338984837 | interleukin-6-Stat3 |
miR-331-3p | miR-331-3p | 457 HCC | China | 1.Promotes Proliferation2.Metastasis | up | 2482530270 | Leucine-Rich Repeat Protein Phosphatase |
miR-34a | miR-34a-5p | 120 HCC | China | 1.tumor size2.higher serum AFP level | down | 25596083113 | NA |
miR-424 | miR-424-5p | 96 HCC | China | suppressed proliferation | down | 2631554187 | pRb-E2F pathway, Akt3 and E2F3 |
miR-503 | miR-503-5p | 20 HCC | China | suppress metastasis | down | 2616326075 | PRMT1 |
miR-744 | miR-744-5p | 96 HCC | China | 1.tumour suppressor2.tumor malignancy3.tumor cell proliferation4.invasion and migration5.HCC recurrence6.poor prognosis | down | 2554352176 | NA |
miR-9 | miR-9-5p | 200 HCC | China | 1.tumour suppressor2.tumor stage3.venous infiltration | up | 2555220471 | NA |
miR-96 | miR-96-5p | 81 HCC | China | 1.onco-miR2.motility and invasiveness | up | 2581340366 | FOXO1 |
miR-125a | miR-125a-5p | 80 HCC | China | 1.Proliferation 2.Metastasis | down | 22768249146 | MMP11 and VEGF |
miR-99a | miR-99a-5p | 142 HCC | China | tumor suppressor | down | 21878637147 | NA |
Abbreviations and note: HC: healthy controls; CHB: patients with chronic type B hepatitis; CLD: chronic liver disease; HCV-CLD: non-malignant HCV-associated CLD patients; DN: chronic hepatitis B patients with pathologically proven DN; ICC: intrahepatic cholangiocellular carcinoma; LC: liver cirrhosis; HCV: hepatitis C virus; HBV: hepatitis B virus; CH: chronic hepatitis; TR: treated recurrence group; NTR: none treated recurrence group; NA: not available.