. 2016 Dec 5;6:38311. doi: 10.1038/srep38311

Table 3. Prognostic biomarkers in tissues for hepatocellular carcinoma.

Reported ID	Offical ID	Sample	Ethnicity	Features	Expression	PMID	Validated Targets
miR-101	miR-101-3p	20 HC 25 HBV-HCC	China	1.HBsAg, HBV DNA level and tumor size	up	24260081¹¹²	NA
miR-101	miR-101-3p	130 HCC	China	tumor suppressor	down	23178713⁹⁹	SOX9
miR-101	miR-101-3p	30 HC 79 CHB 61 HBV-LC 67 HBV-HCC	China	1.inhibit HCC cell proliferation2.tumor suppressor	up	24971953³⁸	NA
miR-106b	miR-106b-5p	104 HCC	China	1.tumor size2. vascular invasion3. proliferation4. anchorage-independent growth of HCC cells5.metastasis	up	25466449⁶⁴	NA
miR-122	miR-122-5p	60 HCC	China	1.tumor suppressor2.maintenance of normal physiological metabolism	down	26252254¹⁰⁰	PKM2
miR-125b	miR-125b-5p	49 HCC	China	tumor suppressor	down	24811246¹⁰¹	Eif5a2
miR-1269	miR-1269a	95 HCC	China	1.tumor nodes2.portal vein tumor embolus3.vaso-invasion4.tumor capsular infiltration5.expression of MTDH6.onco-miR7.carcinogenesis, metastasis and invasion of HCC	up	25785048⁷²	AGAP1, AGK, BPTF, C16orf74, DACT1, LIX1L, RBMS3, ZNF706 and BMPER
miR-128-3p	miR-128-3p	72 HCC	China	1.suppress proliferation2.suppress metastasis	down	25962360⁷³	PIK3R1 PI3K/AKT
miR-130a	miR-130a-3p	102 HCC	China	1.gender, HBsAgstatus, tumor size, and TNM stage2.tumor suppressor	down	25218269¹⁰²	NA
miR-137	miR-137	136 HCC	China	1.vein invasion2.distant metastasis3.inhibition promotes HCC cell growth	down	24970808³⁵	AKT2
miR-146a	miR-146a-5p	85 HCC	China	tumor suppressor	down	24172202¹⁰³	ROCK1
miR-155	miR-155-5p	100 HCC	China	1.metastasis2.inhibits apoptosis	up	23863669⁴⁵	NA
miR-155	miR-155-5p	216 HCC	China	onco-miR	up	22629365¹⁰⁸	NA
miR-17-5p	miR-17-5p	120 HCC	China	regulating proliferation and migration	up	22583011⁶⁵	p38 MAPK-HSP27
miR-182	miR-182-5p	81 HCC	China	1.onco-miR2.motility and invasiveness	up	25813403⁶⁶	FOXO1
miR-182	miR-182-5p	86 HCC	China	intrahepatic metastasis	up	22681717⁶⁷	MTSS1
miR-183	miR-183-5p	81 HCC	China	1.onco-miR2.motility and invasiveness	up	25813403⁶⁶	FOXO1
miR-185	miR-185-5p	41 NTR 54 TR	China	1.suppress the tumor cell growth2.suppress invasive	down	23648054³⁶	NA
miR-188-5p	miR-188-5p	250 HCC	China	1.suppress tumor cell proliferation2.suppress metastasis	down	25998163⁷⁴	FGF5
miR-18b	miR-18b-5p	110 HCC	Japan	1.proliferation2.loss of cell adhesion ability	up	23496901⁵²	TNRC6B
miR-199a-5p	miR-199a-5p	120 HCC	China	1.Negatively Associated With Malignancies2.Regulates Glycolysis3.Lactate Production	down	26054020¹⁴⁵	Hexokinase 2
miR-206	miR-206	147 HCC	China	1.suppresses cell proliferation2.promotes apoptosis.	down	25513086⁴⁶	NA
miR-21	miR-21-5p	50 HC 30 CH 136 HCC	Japan	NA	down	21749846¹¹⁰	NA
miR-21	miR-21-5p	112 HCC	China	1.tumor differentiation2.TNM stage3.vein invasion	up	26261620⁶⁸	NA
miR-21	miR-21-5p	119 HCC	China	1.tumorinvasion, metastasis and prognosis2.promote cell proliferation and invasion3.inhibits cell apoptosis	up	25150373⁴⁷	NA
miR-21	miR-21-5p	74 ICC	China	intrahepatic cholangiocarcinoma proliferation and growth	up	25803229⁵⁶	PTPN14 and PTEN
miR-212	miR-212-3p	86 HCC	China	1.inhibited cell proliferation2.induced apoptosis	down	26347321⁴⁸	FOXA1
miR-214	miR-214-3p	65 HCC	China	tumor suppressor	down	23962428¹⁰⁴	FGFR-1
miR-25	miR-25-3p	96 HCC	Iran	1.TNM stage2.suppress proliferation3.suppress migration	up	26209296⁶⁹	NA
miR-26a	miR-26a-5p	120 HCC	China	1.Cell Cycle2.angiogenesis	up	24259426⁸⁴	CDK6, cyclin D1
miR-26a	miR-26a-5p	130 HCC	China	1.suppress the tumor cell growth2.suppress invasive	down	23389848³⁷	interleukin-6-Stat3
miR-331-3p	miR-331-3p	457 HCC	China	1.Promotes Proliferation2.Metastasis	up	24825302⁷⁰	Leucine-Rich Repeat Protein Phosphatase
miR-34a	miR-34a-5p	120 HCC	China	1.tumor size2.higher serum AFP level	down	25596083¹¹³	NA
miR-424	miR-424-5p	96 HCC	China	suppressed proliferation	down	26315541⁸⁷	pRb-E2F pathway, Akt3 and E2F3
miR-503	miR-503-5p	20 HCC	China	suppress metastasis	down	26163260⁷⁵	PRMT1
miR-744	miR-744-5p	96 HCC	China	1.tumour suppressor2.tumor malignancy3.tumor cell proliferation4.invasion and migration5.HCC recurrence6.poor prognosis	down	25543521⁷⁶	NA
miR-9	miR-9-5p	200 HCC	China	1.tumour suppressor2.tumor stage3.venous infiltration	up	25552204⁷¹	NA
miR-96	miR-96-5p	81 HCC	China	1.onco-miR2.motility and invasiveness	up	25813403⁶⁶	FOXO1
miR-125a	miR-125a-5p	80 HCC	China	1.Proliferation 2.Metastasis	down	22768249¹⁴⁶	MMP11 and VEGF
miR-99a	miR-99a-5p	142 HCC	China	tumor suppressor	down	21878637¹⁴⁷	NA

Abbreviations and note: HC: healthy controls; CHB: patients with chronic type B hepatitis; CLD: chronic liver disease; HCV-CLD: non-malignant HCV-associated CLD patients; DN: chronic hepatitis B patients with pathologically proven DN; ICC: intrahepatic cholangiocellular carcinoma; LC: liver cirrhosis; HCV: hepatitis C virus; HBV: hepatitis B virus; CH: chronic hepatitis; TR: treated recurrence group; NTR: none treated recurrence group; NA: not available.