Fig. 3.

Overview of voltage-clamp simulation mode in LongQt. (A) Example of “Set Sim. Parameters” panel for voltage-clamp protocol. Representative (B) transmembrane potential (vOld) and (C) sodium current (iNa) vs. time for a Grandi Atrial model voltage clamp simulation, with simulation parameters specified in A. Abbreviations are as follows: t1-t5, timepoints at which voltage is changed (ms); v1-v5, transmembrane potential corresponding to timepoints t1-t5 (mV); tMax, maximum duration of simulation (ms); writetime, time to begin writing/analyzing model variables (ms).