Table 2. Logistic regression models (1–3) predicting fatty liver (FL_All or FL_C) with hsa-miR-122-5p or -885-5p and known risk factors and biomarkers of FL.

Outcome	MODEL 1		MODEL 2		MODEL 3
	miR-122	miR-885	miR-122	miR-885	miR-122	miR-885
NL vs. FLAll
n	703	871	701	868	632	781
p-value	1.26 * 10−14	3.91 * 10−6	1.29 * 10−8	0.002	6.84 * 10−5	0.131
OR	2.44	1.55	2.07	1.41	1.78	1.23
95% CI	1.96–3.09	1.29–1.86	1.62–2.68	1.13–1.77	1.35–2.38	0.94–1.60
NL vs. FLC
n	600	752	598	749	545	681
p-value	5.59 * 10−9	1.33 * 10−4	1.93 * 10−6	9.83 * 10−4	2.48 * 10−3	0.353
OR	4.61	2.14	6.67	2.47	3.64	1.37
95% CI	2.83–7.96	1.46–3.19	3.28–15.97	1.46–4.33	1.69–9.29	0.71–2.73

MODEL 1: *Stepwise logistic regression model predicting FL (either FL_All or FL_C) with miR-122-5p or miR-885-5p (one by one forced into model).

MODEL 2: Model 1+ age, sex and BMI.

MODEL 3: Model 2+ alcohol consumption, waist circumference, apolipoprotein B levels, triglycerides, insulin levels, systolic blood pressure, smoking, and physical activity index. This model involves all the explanatory variables that have been previously associated with liver status in Young Finns Study [see ref. 6] excluding liver enzymes due to high correlation with studied miRNAs.

Abbreviations: NL = Normal liver, FL = fatty liver, FL_All = all subjects with fatty liver, FL_C = clearly identified fatty liver, miR-122 = hsa-miR-122-5p, miR-885 = hsa-miR-885-5p.