Table 3. Correlation and adjusted linear regressions between hsa-miR-122-5p and -885-5p and serum liver enzyme levels.

	Spearman correlation				Linear regression model*
	n	p	pc	r	n	p	ß (95% CI)
Hsa-miR-122-5p
ALT	703	5.01 * 10−33	1.22 * 10−30	0.43	701	1.07 * 10−25	0.319 (0.262–0.376)
AST	703	4.49 * 10−26	1.09 * 10−23	0.384	701	3.43 * 10−22	0.321 (0.258–0.384)
GT	703	5.43 * 10−17	1.32 * 10−14	0.309	701	2.10 * 10−7	0.163 (0.102–0.224)
Hsa-miR-885-5p
ALT	868	3.78 * 10−19	9.18 * 10−17	0.297	868	9.33 * 10−14	0.377 (0.149–0.252)
AST	868	1.71 * 10−16	4.16 * 10−14	0.275	868	4.19 * 10−12	0.205 (0.148–0.262)
GT	868	1.26 * 10−08	3.05 * 10−6	0.192	868	4.97 * 10−4	0.096 (0.042–0.150)

^*Statistical model: Stepwise linear regression model predicting liver enzyme levels (one by one) with miR-122-5p or miR-885-5p (one by one forced into model), age, sex, BMI, and liver status. Abbreviations: ALT = Alanine aminotransferase, AST = Aspartate aminotransferase, GT = gamma-glutamyltransferase, r = correlation estimate, p_c = Bonferroni corrected p-value. Betas (β) indicates the standard deviation (SD) change of the liver enzyme levels per increase of one SD of miRNA levels.