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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: J Asthma. 2016 Apr 6;53(8):775–782. doi: 10.3109/02770903.2016.1158268

Table 5.

eQTL and GWAS of RAD50-IL13 region

SNP Gene Location Distance
to Gene		 Minor
Allele		 Major
Allele		 MAF IL13 expression RAD50 expression GWAS
BEC BAL BEC BAL TENOR GABRIEL
Beta P value Beta P value Beta P value Beta P value OR P value OR P value
rs4143832 IL5 3′ −14159 A C 0.23 −0.22 0.18 0.20 0.25 0.18 0.27 0.26 0.13 1.23 0.05 1.07 9.9×10−3
rs11739623 IL5 3′ −12984 T C 0.18 0.01 0.94 −0.04 0.81 −0.28 0.10 −0.65 7.1×10−5 0.91 0.33 0.94 4.4×10−3
rs2079103 IL5 3′ −12630 T G 0.33 −0.14 0.32 −0.01 0.96 0.25 0.07 0.27 0.08 1.06 0.52 1.06 0.02
rs17690122 IL5 3′ −9301 G A 0.17 −0.06 0.74 0.22 0.26 0.19 0.31 0.25 0.19 1.22 0.06 NA NA
rs743562 IL5 3′ −4753 T C 0.34 0.06 0.70 0.10 0.50 −0.07 0.61 −0.32 0.02 1.06 0.52 0.98 0.31
rs739719 IL5 3′ −4271 T G 0.22 −0.22 0.14 −0.20 0.23 0.11 0.44 0.09 0.59 0.79 0.17 1.01 0.78
rs2069812 IL5 5′ −702 T C 0.43 −0.10 0.45 −0.10 0.50 −0.13 0.33 −0.58 5.8×10−5 0.85 0.07 0.93 3.5×10−3
rs2244012 RAD50 intron −6166 C T 0.38 −0.21 0.11 0.19 0.18 0.10 0.47 0.05 0.71 1.64 3.0×10−7 NA NA
rs2301713 RAD50 intron −174 C T 0.29 −0.15 0.34 0.29 0.07 0.13 0.42 0.23 0.16 1.59 1.5×10−6 NA NA
rs17772583 RAD50 intron −252 G A 0.17 0.03 0.87 −0.01 0.96 −0.37 0.04 −0.85 7.4×10−7 0.89 0.23 0.92 3.4×10−4
rs3798134 RAD50 intron −7628 T C 0.30 −0.18 0.21 0.33 0.03 0.12 0.44 0.19 0.23 1.59 1.5×10−6 NA NA
rs2237060 RAD50 intron −1922 C A 0.29 0.16 0.29 −0.26 0.11 0.09 0.55 0.38 0.02 0.88 0.12 0.95 0.02
rs1881457 IL13 5′ −1456 C A 0.23 0.02 0.89 0.38 0.02 0.14 0.36 0.26 0.10 NA NA NA NA
rs1295686 IL13 intron −24 A G 0.42 −0.08 0.55 0.20 0.18 0.05 0.73 0.06 0.67 1.45 2.2×10−4 1.15 1.4×10−8
rs20541 IL13 coding 97_10 T C 0.25 0.05 0.76 0.32 0.07 0.17 0.27 0.12 0.48 1.44 2.5×10−4 1.15 2.0×10−8
rs1295685 IL13 3UTR 470_356 T C 0.21 −0.04 0.80 0.31 0.08 0.19 0.25 0.20 0.26 1.49 7.4×10−5 NA NA
rs848 IL13 3UTR 525_301 T G 0.38 0.00 0.99 0.21 0.18 0.10 0.51 0.06 0.71 1.49 7.6×10−5 NA NA
rs2243204 IL13 3′ −2693 T C 0.26 −0.04 0.81 0.00 0.98 −0.07 0.64 −0.11 0.50 1.69 1.3×10−4 1.19 5.3×10−7
rs2243248 IL4 5′ −729 G T 0.11 0.43 0.05 −0.04 0.89 0.06 0.79 0.05 0.83 0.91 0.52 1.00 0.91
rs2070874 IL4 5UTR 337_32 T C 0.28 −0.07 0.61 0.12 0.41 0.16 0.24 0.08 0.60 1.12 0.34 NA NA
rs2243268 IL4 intron −1443 C A 0.23 −0.04 0.80 0.11 0.50 0.19 0.19 0.19 0.23 1.11 0.38 NA NA
rs2243290 IL4 intron −9 A C 0.25 −0.02 0.88 0.10 0.52 0.14 0.34 0.14 0.36 1.11 0.38 1.08 5.5×10−3
*

SNPs were in two separate linkage disequilibrium blocks (r2>0.5). Block 1 includes rs11739623, rs2069812, and rs17772583. Block 2 includes rs2244012, rs2301713, rs3798134, rs1881457, rs1295686, rs20541, rs1295685, rs848, and rs2243204.