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. Author manuscript; available in PMC: 2016 Dec 5.
Published in final edited form as: J Clin Pharmacol. 2011 Dec 12;52(9):1306–1316. doi: 10.1177/0091270011419854

Figure 3.

Figure 3

Effect of MK-5046 on blood pressure, heart rate, and body temperature. Data are change from the baseline (0 hours, which is nominally 0800) for placebo (red circles; n = 27, except n = 22 at the 5- and 6-hour points), 120 mg (open triangles; n = 12/group), 120 mg twice (black squares; second dose at 6 hours, n = 11/group), and 160 mg (open diamonds; n = 12/group) MK-5046 doses. Data are arithmetic mean ± standard error. Placebo time points sampled only with the twice-dosing cohort had an n = 5 and were omitted.