. Author manuscript; available in PMC: 2016 Dec 5.

Published in final edited form as: J Clin Pharmacol. 2011 Dec 12;52(9):1306–1316. doi: 10.1177/0091270011419854

Table I.

Pharmacokinetic Parameters for MK-5046 in Young Men Following Ingestion of Single Oral Doses

Dose, mg	Panel	N	AuC_0-∞, nM·h^a		C_max, nM^a		T_max, h		Apparent t_1/2, h
Dose, mg	Panel	N	GM	95% CI	GM	95% CI	Median	Minimum-Maximum	HM	Pseudo-SD
10	A	6^b	147	96-224	91	61-135	0.75	0.50-1.50	1.05	0.63
20	A	6	244	162-368	163	110-241	0.50	0.25-1.00	1.36	0.93
40	A	6	396	263-597	287	193-426	0.75	0.50-1.00	1.31	0.53
40	B	6	716	465-1100	471	312-711	1.00	0.25-1.50	1.95	0.42
40, fed	B	6	815	530-1260	282	187-426	2.50	0.25-4.00	2.06	0.56
80	A	6	1170	777-1760	738	497-1100	1.00	0.50-1.50	1.74	0.63
80, obese	C	8	1860	1250-2760	836	574-1220	1.25	0.50-2.00	2.55	0.71
120	B	6	3370	2190-5170	1270	846-1920	1.25	0.50-2.00	2.28	0.66
120, obese	C	6	3540	2330-5370	1250	835-1880	1.25	0.50-2.00	2.72	0.54
160	A	6	3000	1990-4520	1280	860-1900	0.75	0.50-1.00	2.21	0.65
160	B	6	4460	2900-6860	1830	1220-2770	1.00	1.00-1.50	2.22	0.57

GM, geometric mean; HM, harmonic mean.

Back-transformed least squares mean and 95% confidence interval (CI) from mixed-effects model performed on natural log-transformed values.

n = 5 for t_1/2 and AUC_0-∞ at this dose because one patient had concentrations below the limit of quantitation.