Figure 4.

L1 CDR and glycan-binding site. (a) Main-chain superposition of N14 L1 CDR (yellow sticks) with the ‘canonical conformation structure 1’ (green sticks; PDB entry 2fbj; Al-Lazikani et al., 1997 ▸). The glycosylation at Asn26L located at the onset of the hypervariable region has little effect on the canonical L1 conformation. (b) The glycan fragments in N14 (yellow sticks) and PDB entry 2igf (green sticks; Stanfield et al., 1990 ▸) cannot possibly assume the same conformation despite a very similar loop arrangement around Asn26L, because a symmetry-related molecule in N14 (thin blue sticks) would interfere with the 2igf glycan conformation in the case of N14. This figure was displayed and rendered with Coot (Emsley et al., 2010 ▸).