Table 3. Sequences of the six hypervariable loops of the complementarity-determining regions (CDRs) of the afamin-binding region depicted in Fig. 2 ▸ .
CDR region | Residues | Remarks |
---|---|---|
L1 (L24–L34) | TANSSVSSNYFH | Asn26L glycosylated |
Canonical L1 | -ASSSVSS- | |
L2 (L50–L56) | STSNLAS | Ser51L in high-energy conformation |
L3 (L89–L97) | HQYHRSPPT | |
H1 (H31–H35) | SYIIH | |
H2 (H50–H65) | YINPYNDGSKYNEKFKG | Asp55H in K+-mediated crystal contact |
H3 (H95–H102) | NYWSDSLDY |