Figure 1.

Genomic and structural characteristics of chikungunya virus (CHIKV). A, Genome organization and functional roles of the nonstructural and structural polyprotein open reading frames, as well as the 26S subgenomic promoter. B and C, Cryo-electron microscopic reconstruction of CHIKV virus-like particles, and enlarged depiction of the trimeric spikes consisting of heterodimers of E1 and E2 envelope glycoproteins (C; adapted from [16] with permission). Abbreviations: E, envelope; TM, transmembrane.