Fig. 3.
Comparison of lasing characteristics between target (red) and single-base-mismatched (black) DNA, 40 bases long: (a) Laser emission intensity as a function of the pump intensity. The lasing thresholds are 150 μJ/mm2 and 530 μJ/mm2 for the target and the single-base-mismatched DNA laser, respectively. The lasing efficiency also shows more than 5-fold decrease for the single-base-mismatched DNA sample. (b) Lasing spectra comparison when pump intensity is 500 μJ/mm2: Target DNA shows clear laser emission similar to Fig. 2(a), while the single-base-mismatch DNA shows zero signal. Through DNA hybridization, temperature is elevated to 55 °C to increase specificity. Note that the curves are vertically shifted for clarity.